Innovative approaches in stem cell therapy: revolutionizing cancer treatment and advancing neurobiology- A comprehensive review.

IF 12.5 2区 医学 Q1 SURGERY
Dhrupad Banerjee, Arghya Bhattacharya, Abhijeet Puri, Shubham Munde, Nobendu Mukerjee, Popat Mohite, Syeda Wajida Kazmi, Abhishek Sharma, Taha Alqahtani, Humood Al Shmrany
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引用次数: 0

Abstract

Stem cell therapy represents a transformative frontier in medical science, offering promising avenues for revolutionizing cancer treatment and advancing our understanding of neurobiology. This review explores innovative approaches in stem cell therapy that have the potential to reshape clinical practices and therapeutic outcomes in cancer and neurodegenerative diseases. In this dynamic and intriguing realm of cancer research, recent years witnessed a surge in attention towards understanding the intricate role of Mesenchymal Stem Cells (MSCs). These cells, capable of either suppressing or promoting tumors across diverse experimental models, have been a focal point in the exploration of exosome-based therapies. Exosomes released by MSCs have played a pivotal role, in unraveling the nuances of paracrine signaling and its profound impact on cancer development. Recent studies have revealed the complex nature of MSC-derived exosomes, showcasing both pro-tumor and anti-tumor effects. Despite their multifaceted involvement in tumor growth, these exosomes show significant promise in influencing both tumor development and chemosensitivity, acting as a pivotal factor that increases stem cells' potential for medicinal use. Endogenous MSCs, primarily originating from the bone marrow, exhibited a unique migratory response to damaged tissue sites. The genetic modification of stem cells, including MSCs, opened avenues for the precise delivery of therapeutic payloads in the milieu around the tumor (TME). Stem cell therapy offers groundbreaking potential for treating neurodegenerative and autoimmune disorders by regenerating damaged tissues and modulating immune responses. This approach aims to restore lost function and promote healing through targeted cellular interventions. In this review, we explored the molecular complexities of cancer and the potential for breakthroughs in personalized and targeted therapies. This analysis offers hope for transformative advancements in both cancer treatment and neurodegenerative disorders, highlighting the promise of precision medicine in addressing these challenging conditions.

干细胞疗法的创新方法:彻底改变癌症治疗,推动神经生物学发展--综合综述。
干细胞疗法代表着医学科学的变革前沿,为彻底改变癌症治疗和增进我们对神经生物学的了解提供了大有可为的途径。这篇综述探讨了干细胞疗法的创新方法,这些方法有可能重塑癌症和神经退行性疾病的临床实践和治疗效果。在这一充满活力、引人入胜的癌症研究领域,近年来,人们对间充质干细胞(MSCs)复杂作用的了解日益加深。这些细胞在不同的实验模型中都能抑制或促进肿瘤的生长,它们一直是探索基于外泌体疗法的焦点。间充质干细胞释放的外泌体在揭示旁分泌信号的细微差别及其对癌症发展的深远影响方面发挥了关键作用。最近的研究揭示了间叶干细胞外泌体的复杂性质,显示了其促肿瘤和抗肿瘤作用。尽管这些外泌体多方面参与了肿瘤生长,但它们在影响肿瘤发生和化疗敏感性方面显示出巨大前景,是提高干细胞药用潜力的关键因素。内源性间充质干细胞主要来源于骨髓,对受损组织部位表现出独特的迁移反应。对干细胞(包括间充质干细胞)进行基因改造,为在肿瘤周围环境(TME)中精确输送治疗载荷开辟了道路。干细胞疗法通过再生受损组织和调节免疫反应,为治疗神经退行性疾病和自身免疫性疾病提供了突破性的潜力。这种方法旨在通过有针对性的细胞干预来恢复丧失的功能并促进愈合。在这篇综述中,我们探讨了癌症分子的复杂性以及个性化和靶向疗法取得突破的潜力。这一分析为癌症治疗和神经退行性疾病的变革性进展带来了希望,凸显了精准医学在应对这些挑战性疾病方面的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
17.70
自引率
3.30%
发文量
0
审稿时长
6-12 weeks
期刊介绍: The International Journal of Surgery (IJS) has a broad scope, encompassing all surgical specialties. Its primary objective is to facilitate the exchange of crucial ideas and lines of thought between and across these specialties.By doing so, the journal aims to counter the growing trend of increasing sub-specialization, which can result in "tunnel-vision" and the isolation of significant surgical advancements within specific specialties.
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