Impact of pesticides exposure and type 2 diabetes risk: a systematic review and meta-analysis.

IF 3.7 3区医学 Q2 Medicine

Endocrine Pub Date : 2024-10-09 DOI:10.1007/s12020-024-04067-w

Yang Chen, Yaqin Deng, Minjia Wu, Peixuan Ma, Wen Pan, Weiqi Chen, Lina Zhao, Xiaowei Huang

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引用次数: 0

Abstract

Objective: We conducted a systematic review and meta-analysis of observational studies that assessed the relationship between pesticides exposure and type 2 diabetes. We also examined the presence of heterogeneity and biases across the available studies.

Methods: We conducted a comprehensive literature search of peer-reviewed studies published from 2011 to 2023, without language limitations. A random-effects model was employed to calculate the overall odds ratio (OR) and its corresponding 95% confidence interval (CI).

Results: We included 19 studies (n = 12 case-control and n = 7 cross-sectional) for a total of 45,813 participants in our analysis. Our findings revealed a notable correlation between pesticide exposure and type 2 diabetes (non-specific definition) when not limiting pesticide types (OR: 1.19, 95% CI: 1.11-1.28). Subgroup analysis identified associations between pyrethroid (OR: 1.17, 95% CI: 1.05-1.30) and type 2 diabetes, as well as between organochlorine (OR: 1.26, 95% CI: 1.11-1.43) and type 2 diabetes. However, no statistically significant association was observed between herbicide exposure and the onset of type 2 diabetes (OR: 1.26, 95% CI: 0.91-1.75). In the elderly group, pesticide exposure significantly heightened the risk of type 2 diabetes (OR: 1.25, 95% CI: 1.14-1.38), with no statistically significant heterogeneity among studies (I² = 14.2%, p = 0.323).

Conclusions: Pesticide (organochlorine and pyrethroid) exposure constitutes a risk factor for type 2 diabetes.

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农药暴露与 2 型糖尿病风险的影响：系统回顾与荟萃分析。

目的我们对评估农药暴露与 2 型糖尿病之间关系的观察性研究进行了系统回顾和荟萃分析。我们还研究了现有研究中是否存在异质性和偏倚：我们对 2011 年至 2023 年间发表的同行评审研究进行了全面的文献检索，没有语言限制。采用随机效应模型计算总的几率比（OR）及其相应的 95% 置信区间（CI）：我们在分析中纳入了 19 项研究（病例对照研究 12 项，横断面研究 7 项），共有 45,813 名参与者。我们的研究结果表明，在不限制农药类型的情况下，农药暴露与 2 型糖尿病（非特异性定义）之间存在明显的相关性（OR：1.19，95% CI：1.11-1.28）。分组分析确定了拟除虫菊酯（OR：1.17，95% CI：1.05-1.30）与 2 型糖尿病之间的关系，以及有机氯（OR：1.26，95% CI：1.11-1.43）与 2 型糖尿病之间的关系。然而，除草剂接触与 2 型糖尿病发病之间没有发现明显的统计学关联（OR：1.26，95% CI：0.91-1.75）。在老年人组中，接触杀虫剂会显著增加 2 型糖尿病的风险（OR：1.25，95% CI：1.14-1.38），不同研究之间没有统计学意义上的显著异质性（I2 = 14.2%，P = 0.323）：结论：农药（有机氯和拟除虫菊酯）暴露是 2 型糖尿病的一个风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.