IL36RN Mutations and Correlated Characteristics in Generalized Pustular Psoriasis Patients in Can Tho City, Vietnam: A Cross-Sectional Study.

IF 3 3区医学 Q2 DERMATOLOGY

Dermatology Pub Date : 2024-01-01 Epub Date: 2024-10-08 DOI:10.1159/000541886

Trang Nguyen Thi Thuy, Kien Trung Nguyen, Bang Le Nguyen, Tam Tran Thi Minh, Hung Do Tran, Hung Gia Tran

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引用次数: 0

Abstract

Introduction: Pustular psoriasis is a rare and severe form of psoriasis characterized by sterile pustules on an erythematous background. The disease ranges from localized to generalized forms, with the latter being particularly life-threatening and recurrent. Understanding the genetic basis of pustular psoriasis, particularly IL36RN mutations, is crucial for developing better treatments. This study aimed to determine the prevalence and types of IL36RN gene mutations and their relationship with clinical and paraclinical features in patients with pustular psoriasis in Can Tho City, Vietnam.

Methods: A cross-sectional study was conducted at Can Tho Dermatology Hospital involving 59 patients diagnosed with generalized pustular psoriasis (GPP) according to ERASPEN and Japanese Dermatological Association criteria. Data on demographic, clinical, and laboratory characteristics were collected. IL36RN gene mutations were identified through genomic DNA sequencing. Statistical analyses were performed to explore associations between IL36RN mutations and clinical features.

Results: The study included 59 participants, predominantly female (69.5%), with an average age of 39.12 years. A significant proportion (83.1%) had a history of psoriasis, with frequent recurrences (94.9%). The most common IL36RN mutation identified was p.Arg10ArgfsX1, present in 44.1% of patients. Other mutations included p.Pro76Leu (20.3%) and p.Arg102Trp (1.7%). Patients with IL36RN mutations were younger and had an earlier disease onset. Significant associations were found between IL36RN mutations and clinical features such as fever (OR = 11, p < 0.0001) and geographic tongue (OR = 14.67, p < 0.0001).

Conclusion: Our study reveals a high prevalence of IL36RN mutations, particularly p.Arg10ArgfsX1, in Vietnamese pustular psoriasis patients, strongly associating these mutations with clinical features like fever and geographic tongue.

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越南芹苴市泛发性脓疱型银屑病患者的 IL36RN 基因突变及相关特征：横断面研究

简介脓疱型银屑病是一种罕见的严重银屑病，其特征是在红斑背景上出现无菌性脓疱。脓疱型银屑病有局部型和全身型之分，其中全身型银屑病尤其危及生命，而且容易复发。了解脓疱型银屑病的遗传基础，尤其是 IL36RN 基因突变，对于开发更好的治疗方法至关重要。本研究旨在确定越南芹苴市脓疱型银屑病患者 IL36RN 基因突变的发生率、类型及其与临床和副临床特征的关系：芹苴皮肤病医院根据 ERASPEN 和日本皮肤病协会的标准，对 59 名被诊断为泛发性脓疱型银屑病（GPP）的患者进行了横断面研究。研究人员收集了有关人口统计学、临床和实验室特征的数据。通过基因组 DNA 测序确定了 IL36RN 基因突变。对IL36RN基因突变与临床特征之间的关系进行了统计分析：研究共纳入 59 名参与者，其中女性占绝大多数（69.5%），平均年龄为 39.12 岁。相当一部分患者（83.1%）有银屑病病史，且经常复发（94.9%）。最常见的IL36RN突变是p.Arg10ArgfsX1，出现在44.1%的患者中。其他突变包括p.Pro76Leu（20.3%）和p.Arg102Trp（1.7%）。有IL36RN突变的患者更年轻，发病时间更早。IL36RN突变与发热（OR=11，p <0.0001）和地理舌（OR=14.67，p <0.0001）等临床特征之间存在显著关联：我们的研究揭示了越南脓疱型银屑病患者中IL36RN突变（尤其是p.Arg10ArgfsX1）的高患病率，这些突变与发热和地理舌等临床特征密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatology 医学-皮肤病学

CiteScore

6.40

自引率

2.90%

发文量

审稿时长

1 months

期刊介绍： Published since 1893, ''Dermatology'' provides a worldwide survey of clinical and investigative dermatology. Original papers report clinical and laboratory findings. In order to inform readers of the implications of recent research, editorials and reviews prepared by invited, internationally recognized scientists are regularly featured. In addition to original papers, the journal publishes rapid communications, short communications, and letters to ''Dermatology''. ''Dermatology'' answers the complete information needs of practitioners concerned with progress in research related to skin, clinical dermatology and therapy. The journal enjoys a high scientific reputation with a continually increasing impact factor and an equally high circulation.