Liposomal Nanoformulation-encapsulated Paclitaxel for Reducing Chemotherapy Side Effects in Lung Cancer Treatments: Recent Advances and Future Outlooks.

IF 3.5 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Kave Mohammad-Jafari, Seyed Morteza Naghib, M R Mozafari
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引用次数: 0

Abstract

Paclitaxel is one notable chemotherapy drug that is used to treat a number of cancers, including lung cancer. Nevertheless, it has drawbacks such as toxicity, low solubility in water, and the emergence of multidrug resistance (MDR). This article reviews the use of liposomal formulations to improve paclitaxel administration and efficacy for lung cancer therapy. Paclitaxel's pharmacological characteristics can be improved by liposomes through increased solubility, extended circulation, passive tumor targeting through leaky vasculature, and decreased side effects. Recent developments in paclitaxel liposomal formulations, including as cationic liposomes, conventional liposomes, targeted liposomes with particular ligands, and liposome-loaded microorganisms, are outlined in this article. In comparison to free paclitaxel, these nanoformulations exhibit enhanced cytotoxicity, cellular uptake, apoptosis, tumor growth suppression, and anticancer effects in lung cancer cell lines and animal models. One efficient way to get around the drawbacks of paclitaxel is to alter its size, makeup, and surface characteristics. This will let the medication accumulate and penetrate tumors more easily, avoid multidrug resistance, and cause less systemic toxicity. The article explores clinical studies showcasing the safety and therapeutic efficacy of liposomal paclitaxel for individuals afflicted with lung cancer. In its entirety, the document provides an in-depth examination of the potential enhancement in paclitaxel's dispersion and anti-tumor impacts through the utilization of liposomal technology when addressing diverse manifestations of lung cancer.

用于减少肺癌化疗副作用的纳米脂质体封装紫杉醇:最新进展与未来展望》。
紫杉醇是一种著名的化疗药物,用于治疗包括肺癌在内的多种癌症。然而,它也有一些缺点,如毒性、水溶性低以及出现多药耐药性(MDR)。本文综述了如何利用脂质体制剂改善紫杉醇的给药和疗效以治疗肺癌。脂质体可通过增加溶解度、延长循环时间、通过渗漏血管被动靶向肿瘤以及减少副作用来改善紫杉醇的药理特性。本文概述了紫杉醇脂质体制剂的最新进展,包括阳离子脂质体、传统脂质体、含有特定配体的靶向脂质体以及装载脂质体的微生物。与游离紫杉醇相比,这些纳米制剂在肺癌细胞系和动物模型中表现出更强的细胞毒性、细胞摄取、细胞凋亡、肿瘤生长抑制和抗癌效果。解决紫杉醇缺点的一个有效方法是改变其大小、组成和表面特征。这将使药物更容易积聚和穿透肿瘤,避免多药耐药性,并减少全身毒性。文章探讨了临床研究,展示了脂质体紫杉醇对肺癌患者的安全性和疗效。全文深入探讨了在治疗各种表现的肺癌时,利用脂质体技术提高紫杉醇分散性和抗肿瘤效果的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current medicinal chemistry
Current medicinal chemistry 医学-生化与分子生物学
CiteScore
8.60
自引率
2.40%
发文量
468
审稿时长
3 months
期刊介绍: Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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