Additive Effect of Blood and Tissue Eosinophilia on Chronic Rhinosinusitis With Nasal Polyps

IF 1.7 4区医学 Q2 OTORHINOLARYNGOLOGY

Clinical Otolaryngology Pub Date : 2024-10-10 DOI:10.1111/coa.14243

Peipei Yang, Yongcong Shen, Wenqing Wang, Yuhong Wang, Yuhui Fan, Jisheng Liu, Dan Zhang

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引用次数: 0

Abstract

Purpose

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a highly heterogeneous disease with varied clinical features and treatment effects. This study aimed to investigate the additive effect of blood and tissue eosinophilia on patients with CRSwNP.

Methods

Based on the blood eosinophil (Beos) count and tissue eosinophil (Teos) count, we divided 144 CRSwNP patients into four groups, analysed their clinical features and histopathologic changes, and investigated their postoperative control.

Results

Patients in the Beos⁺Teos⁺ (blood eosinophil count > 0.3 × 10⁹/L, tissue eosinophil count > 10/HPF) group had a higher incidence of allergic rhinitis (AR) and asthma. Lund-Mackay (LM) scores, hyposmia visual analogue scale (VAS) scores and Global Osteitis Scoring Scale (GOSS) scores were higher in the Beos⁺Teos⁺ group than those in the other groups. Tissue remodelling, such as connective tissue oedema and basement membrane thickening was more severe in the Beos⁺Teos⁺ group compared with other groups. There were more uncontrolled patients after surgery in Beos⁺Teos⁺, Beos⁺Teos⁻ (blood eosinophil count > 0.3 × 10⁹/L, tissue eosinophil count ≤ 10/HPF)and Beos⁻Teos⁺ (blood eosinophil count ≤ 0.3 × 10⁹/L, tissue eosinophil count > 10/HPF)groups compared with the Beos⁻Teos⁻ group.

Conclusions

Eosinophilic inflammation both in blood and tissue was accompanied by more severe clinical features and tissue remodelling. Eosinophilia in blood or tissue indicated poorer disease control after surgery.

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血液和组织嗜酸性粒细胞增多对伴有鼻息肉的慢性鼻炎的叠加效应

目的：慢性鼻炎伴鼻息肉（CRSwNP）是一种高度异质性疾病，其临床特征和治疗效果各不相同。本研究旨在探讨血液和组织嗜酸性粒细胞增多对 CRSwNP 患者的叠加效应：根据血液嗜酸性粒细胞（Beos）计数和组织嗜酸性粒细胞（Teos）计数，我们将 144 例 CRSwNP 患者分为四组，分析他们的临床特征和组织病理学变化，并调查他们的术后控制情况：结果：Beos+Teos+（血液嗜酸性粒细胞计数> 0.3 × 109/L，组织嗜酸性粒细胞计数> 10/HPF）组患者过敏性鼻炎（AR）和哮喘的发病率较高。Beos+Teos+ 组的伦德-马凯（LM）评分、低渗视觉模拟量表（VAS）评分和全球骨炎评分量表（GOSS）评分均高于其他组。与其他组相比，Beos+Teos+组的结缔组织水肿和基底膜增厚等组织重塑更为严重。与 Beos-Teos- 组相比，Beos+Teos+组、Beos+Teos-组（血液中嗜酸性粒细胞计数 > 0.3 × 109/L，组织中嗜酸性粒细胞计数≤ 10/HPF）和 Beos-Teos+ 组（血液中嗜酸性粒细胞计数≤ 0.3 × 109/L，组织中嗜酸性粒细胞计数 > 10/HPF）术后未受控制的患者更多：血液和组织中的嗜酸性粒细胞炎症伴随着更严重的临床特征和组织重塑。血液或组织中的嗜酸性粒细胞增多表明术后疾病控制较差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Otolaryngology 医学-耳鼻喉科学

CiteScore

4.00

自引率

4.80%

发文量

106

审稿时长

>12 weeks

期刊介绍： Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.