Anti-oxidant and antibacterial activities of novel N-sulfonylphtalimide in an ovalbumin-induced inflammation in Wistar rats.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-08 DOI:10.14715/cmb/2024.70.9.16

Ilhem Silini, Zineb Rouibah, Houda Bouraoui, Meriem Ahmida, Sabrina Nedjai, Ismahene Grib, Malika Berredjem, Abd El Ghani Djahoudi, Mahfoud Messarah, Amel Boumendjel

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Abstract

Phthalimide and N-substituted phthalimide have a special structure that helps them to be pharmaceutically useful and biologically active. In this study, we investigated the antioxidant, anti-inflammatory and antibacterial effects of a synthetic phthalimide-containing derivative in an experimental asthma model. In vitro determination of antioxidant and chelating activity was carried out by spectrophotometric methods. The in vivo antioxidant activity was carried out in Wistar rats sensitized to ovalbumin in the experimental model of asthma. Our results reveal that that the synthesized N-sulfonylphthalimide molecule has a scavenging capacity against the free radical 2,2-diphenyl-1-picryl-hydrazyl (DPPH•) and a chelating activity on ferrous ions and revealed its protective capacity against altered markers of oxidative stress in the experimental asthma model. All the previous results were confirmed by the result of the histopathological study of the liver. Moreover, neo-synthesized N-sulfonylphthalimide 2 showed antibacterial activity against Gram-positive and Gram-negative bacteria with interesting MIC values. Finally, our study highlights the anti-inflammatory, anti-asthmatic and antibacterial effects of the N-sulfonylphthalimide molecule, which could potentially be a drug of choice in asthmatic pathology, especially during bacterial superinfections in the respiratory tract.

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新型 N-磺酰酞酰亚胺在卵清蛋白诱导的 Wistar 大鼠炎症中的抗氧化和抗菌活性

邻苯二甲酰亚胺和 N-取代邻苯二甲酰亚胺具有特殊的结构，有助于它们发挥药用和生物活性。在本研究中，我们研究了一种含邻苯二甲酰亚胺的合成衍生物在实验性哮喘模型中的抗氧化、抗炎和抗菌作用。体外抗氧化和螯合活性的测定采用分光光度法。在哮喘实验模型中，对卵清蛋白过敏的 Wistar 大鼠进行了体内抗氧化活性测定。我们的研究结果表明，合成的 N-砜基邻苯二甲酰亚胺分子具有清除自由基 2,2-二苯基-1-吡啶-肼（DPPH-）的能力和对亚铁离子的螯合活性，并揭示了它对实验性哮喘模型中氧化应激标志物改变的保护能力。肝脏组织病理学研究结果证实了上述所有结果。此外，新合成的 N-砜基邻苯二甲酰亚胺 2 对革兰氏阳性菌和革兰氏阴性菌具有抗菌活性，其 MIC 值非常有趣。最后，我们的研究强调了 N-砜基邻苯二甲酰亚胺分子的抗炎、抗哮喘和抗菌作用，它有可能成为治疗哮喘病的首选药物，尤其是在呼吸道细菌超级感染期间。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.