The role of metabolic disorders in the development of atherosclerosis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-08 DOI:10.14715/cmb/2024.70.9.21

Alexander V Blagov, Alexey V Churov, Alexander L Golovyuk, Arthur A Lee, Vasily V Kashtalap, Vasily N Sukhorukov, Alexander N Orekhov

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Abstract

Atherosclerosis is a major risk factor for cardiovascular disease (CVD), which is the leading cause of death worldwide. Atherosclerosis is initiated by endothelial activation, followed by a cascade of events (accumulation of lipids, fibrous elements, and calcification) triggering vasoconstriction and activation of inflammatory pathways. This review focuses on the various stages in the development of atherosclerosis, ranging from endothelial dysfunction to plaque rupture. In addition, disorders of lipid, glucose and amino acid metabolism in atherosclerosis are considered here. The key pathological stages of metabolism disruption and their role in atherosclerosis are considered in detail which may be helpful for the more better understanding of atherosclerosis pathogenesis. Finally, some therapeutic approaches aimed at modulating lipid metabolism will also be presented which show the therapeutic targets (enzymes and transport proteins) which modulation can prevent further deterioration of patients symptoms.

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代谢紊乱在动脉粥样硬化发展中的作用。

动脉粥样硬化是心血管疾病（CVD）的主要风险因素，而心血管疾病是全球死亡的主要原因。动脉粥样硬化由内皮激活开始，随后发生一系列事件（脂质、纤维素和钙化的积累），引发血管收缩和炎症通路的激活。本综述将重点讨论动脉粥样硬化发展的各个阶段，从内皮功能障碍到斑块破裂。此外，本文还讨论了动脉粥样硬化中的脂质、葡萄糖和氨基酸代谢紊乱。详细探讨了代谢紊乱的关键病理阶段及其在动脉粥样硬化中的作用，这可能有助于更好地了解动脉粥样硬化的发病机制。最后，还将介绍一些旨在调节脂质代谢的治疗方法，这些方法显示了调节脂质代谢可防止患者症状进一步恶化的治疗靶点（酶和转运蛋白）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.