A Bidirectional Mendelian Randomization Study of the Causal Association Between Ischemic Stroke, Coronary Heart Disease, and Hydrocephalus

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-10-08 DOI:10.1002/brb3.70090

Wencai Wang, Menghao Liu, Zun Wang, Luyao Ma, Yongqiang Zhao, Wei Ye, Xianfeng Li

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Abstract

Background

The association among coronary heart disease, ischemic stroke, and hydrocephalus remains ambiguous.

Objectives

There is a need for a Mendelian randomization study to evaluate the underlying causality between coronary heart disease, ischemic stroke, and hydrocephalus.

Methods

The data source utilized genome-wide association studies, employing a threshold of p < 5 × 10⁻⁸ to identify single nucleotide polymorphisms strongly linked to ischemic stroke and coronary heart disease as instrumental variables (IVs). Five methods—inverse variance weighted (IVW), Mendelian randomization (MR) Egger, Weighted Median, Weighted mode, and Simple mode—utilized the selected IVs to estimate the causality between ischemic stroke, coronary heart disease, and hydrocephalus.

Results

The IVW demonstrated that ischemic stroke and coronary heart disease serve as risk factors for hydrocephalus (odds ratio [OR] = 1.650, 95% CI: 1.066–2.554, p = 0.025; OR = 1.307, 95% CI: 1.023–1.668, p = 0.032). Both the MR-Egger intercept test and Cochran's Q test affirmed the relative reliability of the IVW analysis results. However, no evidence of a reverse causation was observed between hydrocephalus and coronary heart disease or ischemic stroke.

Conclusions

Coronary heart disease and Ischemic stroke may increase the risk of hydrocephalus.

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缺血性中风、冠心病和脑积水之间因果关系的双向孟德尔随机研究

背景：冠心病、缺血性脑卒中和脑积水之间的关系仍不明确：冠心病、缺血性中风和脑积水之间的关系仍然模糊不清：有必要进行孟德尔随机研究，以评估冠心病、缺血性中风和脑积水之间的潜在因果关系：数据来源于全基因组关联研究，采用 p -8 的阈值确定与缺血性中风和冠心病密切相关的单核苷酸多态性作为工具变量（IV）。五种方法--反方差加权（IVW）、孟德尔随机化（MR）Egger、加权中位数、加权模式和简单模式--利用所选的IV来估计缺血性中风、冠心病和脑积水之间的因果关系：IVW显示缺血性脑卒中和冠心病是脑积水的危险因素（比值比 [OR] = 1.650，95% CI：1.066-2.554，p = 0.025；OR = 1.307，95% CI：1.023-1.668，p = 0.032）。MR-Egger 截距检验和 Cochran's Q 检验都证实了 IVW 分析结果的相对可靠性。但是，没有观察到脑积水与冠心病或缺血性中风之间存在反向因果关系的证据：结论：冠心病和缺血性中风可能会增加脑积水的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464