Coordinating BNIP3/NIX-mediated mitophagy in space and time.

IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Natalie M Niemi, Jonathan R Friedman
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引用次数: 0

Abstract

Mitochondria maintain organellar homeostasis through multiple quality control pathways, including the clearance of defective or unwanted mitochondria by selective autophagy. This removal of mitochondria, mitophagy, is controlled in large part by the outer mitochondrial membrane mitophagy receptors BNIP3 and NIX. While it has long been appreciated that BNIP3 and NIX mediate mitophagy by controlling the recruitment of autophagic machinery to the mitochondrial surface, the requirement for the carefully controlled spatiotemporal regulation of receptor-mediated mitophagy has only recently come to light. Several new factors that regulate the BNIP3/NIX-mediated mitophagy pathway have emerged, and various loss-of-function cell and animal models have revealed the dire consequences of their dysregulation. In this mini-review, we discuss new insights into the mechanisms and roles of the regulation of BNIP3 and NIX and highlight questions that have emerged from the identification of these new regulators.

在空间和时间上协调 BNIP3/NIX 介导的有丝分裂
线粒体通过多种质量控制途径维持细胞器的平衡,包括通过选择性自噬清除有缺陷或不需要的线粒体。这种线粒体清除(线粒体吞噬)在很大程度上受线粒体外膜线粒体吞噬受体 BNIP3 和 NIX 的控制。长期以来,人们一直认为 BNIP3 和 NIX 通过控制线粒体表面自噬机制的招募来介导有丝分裂,但对受体介导的有丝分裂进行仔细的时空调控的要求直到最近才被发现。目前出现了几种调节 BNIP3/NIX 介导的有丝分裂途径的新因子,各种功能缺失细胞和动物模型揭示了它们失调的严重后果。在这篇微型综述中,我们将讨论对 BNIP3 和 NIX 的调控机制和作用的新认识,并重点讨论在发现这些新调控因子的过程中出现的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biochemical Society transactions
Biochemical Society transactions 生物-生化与分子生物学
CiteScore
7.80
自引率
0.00%
发文量
351
审稿时长
3-6 weeks
期刊介绍: Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.
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