HFIP as a versatile solvent in resorcin[n]arene synthesis.

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2024-10-02 eCollection Date: 2024-01-01 DOI:10.3762/bjoc.20.211

Hormoz Khosravi, Valeria Stevens, Raúl Hernández Sánchez

引用次数: 0

Abstract

Herein, we present 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as an efficient solvent for synthesizing resorcin[n]arenes in the presence of catalytic amounts of HCl at ambient temperature and within minutes. Remarkably, resorcinols with electron-withdrawing groups and halogens, which are reported in the literature as the most challenging precursors in this cyclization, are tolerated. This method leads to a variety of 2-substituted resorcin[n]arenes in a single synthetic step with isolated yields up to 98%.

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HFIP 作为合成间苯二酚[n]炔的多功能溶剂。

在此，我们将 1,1,1,3,3,3-hexafluorisopropanol (HFIP) 作为一种高效溶剂，用于在催化盐酸的存在下，在环境温度下几分钟内合成间苯二酚[n]炔。值得注意的是，文献中报道的在这种环化过程中最具挑战性的前驱体--具有抽电子基团和卤素的间苯二酚也可以被容忍。这种方法只需一个合成步骤就能得到各种 2-取代的间苯二酚[n]炔，分离产率高达 98%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

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