Decoding Autoimmune Autonomic Disorders: A Less-Recognized Overlap.

IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY
Annals of Indian Academy of Neurology Pub Date : 2024-09-01 Epub Date: 2024-10-08 DOI:10.4103/aian.aian_394_24
Prachi Mohapatra, Ayush Agarwal, Divya M Radhakrishnan, Achal Kumar Srivastava, Divyani Garg
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引用次数: 0

Abstract

Autoimmune autonomic disorders encompass a spectrum of disorders mediated by immune responses directed against the autonomic nervous system, including the peripheral and central autonomic pathways. While centrally mediated autoimmune autonomic disorders primarily can cause autonomic hyperactivity, peripherally mediated disorders are more common and can cause either locally confined or global autonomic failure. These disorders are often underrecognized owing to vague and varied clinical signs and symptoms. The discovery of specific autoantibodies in the past decade has caused a growing recognition of autoimmune causes for these disorders. The management is also complex, as these disorders often manifest with generalized symptoms, are difficult to diagnose, invoke challenges involving robust establishment of an autoimmune syndrome, and are rare. This article presents an overview of autonomic disorders that have a suspected autoimmune etiology, as well as recent advancements in their diagnosis and management.

解码自身免疫性自主神经紊乱:鲜为人知的重叠。
摘要:自身免疫性自律神经紊乱包括一系列由针对自律神经系统(包括外周和中枢自律神经通路)的免疫反应介导的疾病。中枢介导的自身免疫性自律神经失调主要会导致自律神经亢进,而外周介导的自律神经失调则更为常见,可导致局部局限性或整体性自律神经衰竭。由于临床症状和体征模糊多样,这些疾病往往未被充分认识。近十年来,特异性自身抗体的发现使人们逐渐认识到导致这些疾病的自身免疫原因。由于这些疾病通常表现为全身症状,诊断困难,涉及自身免疫综合征的建立,而且罕见,因此治疗也很复杂。本文概述了疑似自身免疫病因的自律神经失调症,以及诊断和治疗方面的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Indian Academy of Neurology
Annals of Indian Academy of Neurology Nervous System Diseases-
CiteScore
2.20
自引率
11.80%
发文量
293
审稿时长
29 weeks
期刊介绍: The journal has a clinical foundation and has been utilized most by clinical neurologists for improving the practice of neurology. While the focus is on neurology in India, the journal publishes manuscripts of high value from all parts of the world. Journal publishes reviews of various types, original articles, short communications, interesting images and case reports. The journal respects the scientific submission of its authors and believes in following an expeditious double-blind peer review process and endeavors to complete the review process within scheduled time frame. A significant effort from the author and the journal perhaps enables to strike an equilibrium to meet the professional expectations of the peers in the world of scientific publication. AIAN believes in safeguarding the privacy rights of human subjects. In order to comply with it, the journal instructs all authors when uploading the manuscript to also add the ethical clearance (human/animals)/ informed consent of subject in the manuscript. This applies to the study/case report that involves animal/human subjects/human specimens e.g. extracted tooth part/soft tissue for biopsy/in vitro analysis.
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