Cognition in (pre)symptomatic Dutch-type hereditary and sporadic cerebral amyloid angiopathy

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2024-10-10 DOI:10.1002/alz.14171

Rosemarie van Dort, Kanishk Kaushik, Ingeborg Rasing, Reinier G. J. van der Zwet, Manon R. Schipper, Jeroen van der Grond, Sanneke van Rooden, Erik W. van Zwet, Gisela M. Terwindt, Huub A. M. Middelkoop, Ellen P. Hart, Matthias J. P. van Osch, Marianne A. A. van Walderveen, Marieke J. H. Wermer

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引用次数: 0

Abstract

INTRODUCTION

Cerebral amyloid angiopathy (CAA) is a main cause of cognitive dysfunction in the elderly. We investigated specific cognitive profiles, cognitive function in the stage before intracerebral hemorrhage (ICH), and the association between magnetic resonance imaging (MRI) based cerebral small vessel disease (cSVD) burden in CAA because data on these topics are limited.

METHODS

We included Dutch-type hereditary CAA (D-CAA) mutation carriers with and without ICH, patients with sporadic CAA (sCAA), and age-matched controls. Cognition was measured with a standardized test battery. Linear regression was performed to assess the association between MRI-cSVD burden and cognition.

RESULTS

D-CAA ICH− mutation carriers exhibited poorer global cognition and executive function compared to age-matched controls. Patients with sCAA performed worse across all cognitive domains compared to D-CAA ICH+ mutation carriers and age-matched controls. MRI-cSVD burden is associated with decreased processing speed.

DISCUSSION

CAA is associated with dysfunction in multiple cognitive domains, even before ICH, with increased MRI-cSVD burden being associated with slower processing speed.

Highlights

Cognitive dysfunction is present in early disease stages of cerebral amyloid angiopathy (CAA) before the occurrence of symptomatic intracerebral hemorrhage (sICH).
Presymptomatic Dutch-type CAA (D-CAA) mutation carriers show worse cognition than age-matched controls.
More early awareness of cognitive dysfunction in CAA before first sICH is needed.
Increased cerebral small vessel disease CAA-burden on magnetic resonance imaging is linked to a decrease in processing speed.

Abstract Image

查看原文本刊更多论文

荷兰型遗传性和散发性脑淀粉样血管病（症状前）的认知能力。

简介脑淀粉样血管病（CAA）是导致老年人认知功能障碍的主要原因。我们研究了特定的认知概况、脑出血（ICH）前阶段的认知功能以及基于磁共振成像（MRI）的 CAA 中脑小血管疾病（cSVD）负担之间的关联，因为有关这些主题的数据有限：我们纳入了患有或未患有 ICH 的荷兰型遗传性 CAA（D-CAA）突变携带者、散发性 CAA（sCAA）患者以及年龄匹配的对照组。认知能力通过标准化测试进行测量。对MRI-cSVD负担与认知能力之间的关系进行线性回归评估：结果：与年龄匹配的对照组相比，D-CAA ICH突变携带者的整体认知能力和执行功能较差。与D-CAA ICH+突变携带者和年龄匹配的对照组相比，sCAA患者在所有认知领域的表现都较差。MRI-cSVD负担与处理速度下降有关：讨论：CAA与多个认知领域的功能障碍有关，甚至在发生ICH之前也是如此，MRI-cSVD负担的增加与处理速度的减慢有关：在无症状性脑出血（sICH）发生之前，脑淀粉样血管病（CAA）的早期疾病阶段就会出现认知功能障碍。无症状的荷兰型CAA（D-CAA）突变携带者的认知能力比年龄匹配的对照组差。在首次发生 sICH 之前，需要更早地认识到 CAA 的认知功能障碍。磁共振成像中脑小血管疾病 CAA 负担的增加与处理速度的下降有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.