Biotechnological advances in microbial synthesis of gold nanoparticles: Optimizations and applications.

IF 2.6 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
3 Biotech Pub Date : 2024-11-01 Epub Date: 2024-10-07 DOI:10.1007/s13205-024-04110-7
Jyoti Verma, Chitranjan Kumar, Monica Sharma, Sangeeta Saxena
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引用次数: 0

Abstract

This review discusses the eco-friendly and cost-effective biosynthesis of gold nanoparticles (AuNPs) in viable microorganisms, focusing on microbes-mediated AuNP biosynthesis. This process suits agricultural, environmental, and biomedical applications, offering renewable, eco-friendly, non-toxic, sustainable, and time-efficient methods. Microorganisms are increasingly used in green technology, nanotechnology, and RNAi technology, but several microorganisms have not been fully identified and characterized. Bio-nanotechnology offers eco-friendly and sustainable solutions for nanomedicine, with microbe-mediated nanoparticle biosynthesis producing AuNPs with anti-oxidation activity, stability, and biocompatibility. Ultrasmall AuNPs offer rapid distribution, renal clearance, and enhanced permeability in biomedical applications. The review explores nano-size dependent biosynthesis of AuNPs by bacteria, fungi, and viruses revealing their non-toxic, non-genotoxic, and non-oxidative properties on human cells. AuNPs with varying sizes and shapes, from nitrate reductase enzymes, have shown potential as a promising nano-catalyst. The synthesized AuNPs, with negative charge capping molecules, have demonstrated antibacterial activity against drug-resistant Pseudomonas aeruginosa, and Acinetobacter baumannii strains, and were non-toxic to Vero cell lines, indicating potential antibiotic resistance treatments. A green chemical method for the biosynthesis of AuNPs using reducing chloroauric acid and Rhizopus oryzae protein extract has been described, demonstrating excellent stability and strong catalytic activity. AuNPs are eco-friendly, non-toxic, and time-efficient, making them ideal for biomedical applications due to their antioxidant, antidiabetic, and antibacterial properties. In addition to the biomedical application, the review also highlights the role of microbially synthesized AuNPs in sustainable management of plant diseases, and environmental bioremediation.

微生物合成金纳米粒子的生物技术进展:优化与应用。
本综述讨论了在有生命力的微生物中以生态友好和具有成本效益的方式进行金纳米粒子(AuNPs)的生物合成,重点是微生物介导的 AuNPs 生物合成。这一工艺适合农业、环境和生物医学应用,提供了可再生、生态友好、无毒、可持续和省时的方法。微生物在绿色技术、纳米技术和 RNAi 技术中的应用越来越广泛,但有几种微生物尚未得到充分鉴定和表征。生物纳米技术为纳米医学提供了生态友好和可持续的解决方案,微生物介导的纳米粒子生物合成产生了具有抗氧化活性、稳定性和生物相容性的 AuNPs。超小 AuNPs 在生物医学应用中具有快速分布、肾脏清除和更强的渗透性。这篇综述探讨了细菌、真菌和病毒根据纳米尺寸进行的 AuNPs 生物合成,揭示了它们对人体细胞无毒、无遗传毒性和无氧化作用的特性。来自硝酸还原酶酶的不同大小和形状的 AuNPs 已显示出作为一种前景广阔的纳米催化剂的潜力。合成的带有负电荷封端分子的 AuNPs 对耐药性铜绿假单胞菌和鲍曼不动杆菌菌株具有抗菌活性,而且对 Vero 细胞系无毒,表明具有治疗抗生素耐药性的潜力。该研究介绍了一种利用还原性氯金酸和根瘤菌蛋白提取物生物合成 AuNPs 的绿色化学方法,该方法具有极佳的稳定性和较强的催化活性。AuNPs 具有环保、无毒、省时等特点,因其抗氧化、抗糖尿病和抗菌特性而成为生物医学应用的理想选择。除生物医学应用外,该综述还强调了微生物合成的 AuNPs 在植物病害可持续管理和环境生物修复方面的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
3 Biotech
3 Biotech Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)
CiteScore
6.00
自引率
0.00%
发文量
314
期刊介绍: 3 Biotech publishes the results of the latest research related to the study and application of biotechnology to: - Medicine and Biomedical Sciences - Agriculture - The Environment The focus on these three technology sectors recognizes that complete Biotechnology applications often require a combination of techniques. 3 Biotech not only presents the latest developments in biotechnology but also addresses the problems and benefits of integrating a variety of techniques for a particular application. 3 Biotech will appeal to scientists and engineers in both academia and industry focused on the safe and efficient application of Biotechnology to Medicine, Agriculture and the Environment.
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