Mimicry games: NPC-like MX2 condensates trap viruses

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2024-10-09 DOI:10.1016/j.chom.2024.09.001

Junfeng Zhou, Wei Wei

引用次数: 0

Abstract

Recent findings suggest that HIV-1 capsids mimic nuclear transport receptors to engage FG-nucleoporins for entry into host nuclei. In this issue of Cell Host & Microbe, Moschonas et al. report that MX2 forms cytoplasmic condensates comprising FG-nucleoporins resembling nuclear pore complexes to capture viral capsids and hinder their nuclear transport.

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模仿游戏类似 NPC 的 MX2 凝聚物捕获病毒

最近的研究结果表明，HIV-1 的噬菌体能模拟核转运受体，使 FG 核蛋白参与进入宿主细胞核。在本期《细胞宿主与amp; 微生物》（Cell Host & Microbe）杂志上，Moschonas 等人报告说，MX2 形成了由类似核孔复合体的 FG-核orins 组成的细胞质凝聚体，以捕获病毒衣壳并阻碍其核运输。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.