Superficial ice and deep blaze: A defense strategy of the skin

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2024-10-08 DOI:10.1016/j.immuni.2024.09.008

Zhuoqiong Qiu, Wei Li

引用次数: 0

Abstract

It’s crucial for skin to establish efficient defense strategies. Liu et al. reveal that the transcription factor ZNF750 recruits the histone demethylase KDM1A to silence pattern recognition receptors in the outer epidermis, making their expression limited to deeper, undifferentiated keratinocytes to address threats penetrating the skin.

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表层结冰和深层灼伤：皮肤的防御策略

这对皮肤建立有效的防御策略至关重要。Liu等人揭示了转录因子ZNF750招募组蛋白去甲基化酶KDM1A来沉默表皮外层的模式识别受体，使其表达局限于更深层的未分化角质细胞，以应对穿透皮肤的威胁。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.