Opportunistic Infections in HIV-Infected Children on Treatment in Southern Morocco: A 12-Years Retrospective Follow-up Study.

IF 2.8 Q2 INFECTIOUS DISEASES
Hayat Iziki, Souad Yakini, Raja Ouabich, Abdelaaziz Bounabe, Nezha Doukkani, Naima Ben-Abjaou, Sanae Ben Taleb, Hicham Blaak, Amal Boutib, Amina Barkat
{"title":"Opportunistic Infections in HIV-Infected Children on Treatment in Southern Morocco: A 12-Years Retrospective Follow-up Study.","authors":"Hayat Iziki, Souad Yakini, Raja Ouabich, Abdelaaziz Bounabe, Nezha Doukkani, Naima Ben-Abjaou, Sanae Ben Taleb, Hicham Blaak, Amal Boutib, Amina Barkat","doi":"10.3947/ic.2024.0056","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Human immunodeficiency virus (HIV) infection in children is a significant public health concern, increasing the risk of infant mortality. Immunodeficiency caused by HIV favors the development of opportunistic infections (OIs), which are responsible for over 90% of HIV-related deaths. This study seeks to determine the primary OIs in children with HIV followed at the Hassan II Regional Hospital Center in Sous Massa, during the period from 2012 to 2023.</p><p><strong>Materials and methods: </strong>This retrospective study is the first in Morocco to investigate OIs among HIV-infected children. It analyzed 76 complete medical records, using a data collection form designed based on existing literature.</p><p><strong>Results: </strong>This study revealed that 37% of participants were suffering from OIs, mainly diarrhea (11%), tuberculosis (9%) and pneumonia (7%).There was a significant correlation between OIs and HIV clinical stage (<i>P=</i>0.001), age (<i>P</i>=0.007), and anemia (<i>P</i>=0.001). Despite progress in management, the presence of OIs remains a risk factor for infant morbidity and mortality.</p><p><strong>Conclusion: </strong>The study highlights the importance of early detection, prevention, and adherence to treatment in reducing this burden. Management of anemia is essential.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458494/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infection and Chemotherapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3947/ic.2024.0056","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Human immunodeficiency virus (HIV) infection in children is a significant public health concern, increasing the risk of infant mortality. Immunodeficiency caused by HIV favors the development of opportunistic infections (OIs), which are responsible for over 90% of HIV-related deaths. This study seeks to determine the primary OIs in children with HIV followed at the Hassan II Regional Hospital Center in Sous Massa, during the period from 2012 to 2023.

Materials and methods: This retrospective study is the first in Morocco to investigate OIs among HIV-infected children. It analyzed 76 complete medical records, using a data collection form designed based on existing literature.

Results: This study revealed that 37% of participants were suffering from OIs, mainly diarrhea (11%), tuberculosis (9%) and pneumonia (7%).There was a significant correlation between OIs and HIV clinical stage (P=0.001), age (P=0.007), and anemia (P=0.001). Despite progress in management, the presence of OIs remains a risk factor for infant morbidity and mortality.

Conclusion: The study highlights the importance of early detection, prevention, and adherence to treatment in reducing this burden. Management of anemia is essential.

摩洛哥南部接受治疗的艾滋病病毒感染儿童的机会性感染:一项为期 12 年的回顾性随访研究。
背景:儿童感染人类免疫缺陷病毒(HIV)是一个重大的公共卫生问题,会增加婴儿死亡的风险。艾滋病病毒导致的免疫缺陷有利于机会性感染(OIs)的发生,90%以上与艾滋病病毒相关的死亡都是由机会性感染造成的。本研究旨在确定 2012 年至 2023 年期间在苏萨马萨哈桑二世地区医院中心接受治疗的艾滋病病毒感染儿童的主要 OIs:这项回顾性研究是摩洛哥首次对感染艾滋病病毒的儿童进行OIs调查。研究使用根据现有文献设计的数据收集表,对 76 份完整病历进行了分析:这项研究显示,37% 的参与者患有 OIs,主要是腹泻(11%)、肺结核(9%)和肺炎(7%)。OIs 与 HIV 临床阶段(P=0.001)、年龄(P=0.007)和贫血(P=0.001)之间存在显著相关性。尽管在管理方面取得了进展,但 OIs 的存在仍然是婴儿发病和死亡的一个风险因素:本研究强调了早期发现、预防和坚持治疗对减轻这一负担的重要性。贫血管理至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Infection and Chemotherapy
Infection and Chemotherapy INFECTIOUS DISEASES-
CiteScore
6.60
自引率
11.90%
发文量
71
审稿时长
22 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信