Increased Risk of Chronic Respiratory Disease among Individuals with Inflammatory Bowel Disease in a Prospective Cohort Study

IF 2.5 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

American Journal of Medicine Pub Date : 2025-01-01 DOI:10.1016/j.amjmed.2024.09.001

Lintao Dan MBBS , Ying Xie MM , Tian Fu MD , Yuhao Sun MM , Xuejie Chen MM , Xiaoyan Wang MD, PhD , Chenkai Wu PhD , Jie Chen PhD , Xue Li PhD

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Abstract

Background

Cross-sectional evidence suggests a higher burden of chronic respiratory diseases in people with inflammatory bowel disease, but there is a lack of prospective evidence to clarify the direction of their associations. We aimed to investigate the association of inflammatory bowel disease with the risk of 2 major chronic respiratory diseases, chronic obstructive pulmonary disease, and asthma.

Methods

We included 430,414 participants from UK Biobank and followed them from recruitment (2006-2010) to 2021. Chronic obstructive pulmonary disease and asthma cases were obtained from inpatient data and death register. Using Cox proportional hazards models, we estimated the multivariable-adjusted hazard ratios (HR) of developing chronic obstructive pulmonary disease and asthma in participants with inflammatory bowel disease compared with inflammatory bowel disease-free groups. We also investigated the association among Crohn's disease and ulcerative colitis with the risk of chronic obstructive pulmonary disease and asthma.

Results

Over a median follow-up of 11.9 years, there were 11,196 incidents of chronic obstructive pulmonary disease and 9831 asthma cases. The adjusted HRs of developing chronic obstructive pulmonary disease (HR 1.54; 95% confidence interval [CI], 1.33-1.79) and asthma (HR 1.52; 95% CI, 1.29-1.79) were higher for those with inflammatory bowel disease when compared with inflammatory bowel disease-free participants. Participants with Crohn's disease and ulcerative colitis were also found to have a higher risk of chronic obstructive pulmonary disease (Crohn's disease: HR 1.71; 95% CI, 1.36-2.15; ulcerative colitis: HR 1.45; 95% CI, 1.20-1.75) and asthma (Crohn's disease: HR 1.73; 95% CI, 1.33-2.25; ulcerative colitis: HR 1.41; 95% CI, 1.15-1.73) when compared with those free of inflammatory bowel disease.

Conclusions

This study suggested that individuals with inflammatory bowel disease have a higher risk of developing chronic obstructive pulmonary disease and asthma, highlighting the importance of preventing chronic respiratory diseases among inflammatory bowel disease patients.

查看原文本刊更多论文

在一项前瞻性队列研究中，炎症性肠病患者罹患慢性呼吸道疾病的风险增加。

背景：横断面证据表明，炎症性肠病患者的慢性呼吸道疾病负担较重，但缺乏前瞻性证据来明确两者之间的关联方向。目的：研究炎症性肠病与慢性阻塞性肺病和哮喘这两种主要慢性呼吸道疾病风险之间的关联：我们纳入了英国生物库中的 430,414 名参与者，并对他们进行了从招募（2006-2010 年）到 2021 年的跟踪调查。慢性阻塞性肺病和哮喘病例来自住院病人数据和死亡登记。我们使用 Cox 比例危险模型估算了与无炎症性肠病组相比，患有炎症性肠病的参与者罹患慢性阻塞性肺病和哮喘的多变量调整危险比 (HR)。我们还调查了克罗恩病和溃疡性结肠炎与慢性阻塞性肺病和哮喘风险之间的关系：在中位 11.9 年的随访期间，共有 11196 例慢性阻塞性肺病和 9831 例哮喘。与无炎症性肠病的参与者相比，患有炎症性肠病的参与者罹患慢性阻塞性肺病（HR=1.54，95% CI：1.33-1.79）和哮喘（HR=1.52，95% CI：1.29-1.79）的调整后HR值更高。研究还发现，患有克罗恩病和溃疡性结肠炎的参与者罹患慢性阻塞性肺病的风险更高（克罗恩病：HR=1.71；95% CI：1.29-1.79）：HR=1.71；95% CI：1.36-2.15；溃疡性结肠炎：HR=1.45；95% CI：1.20-1.75）和哮喘（克罗恩病：与无炎症性肠病的人相比，哮喘（克罗恩病：HR=1.73；95%CI：1.33-2.25；溃疡性结肠炎：HR=1.41；95%CI：1.15-1.73）的发病率更高：这项研究表明，炎症性肠病患者罹患慢性阻塞性肺病和哮喘的风险较高，这凸显了炎症性肠病患者预防慢性呼吸系统疾病的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Medicine 医学-医学：内科

CiteScore

6.30

自引率

3.40%

发文量

449

审稿时长

9 days

期刊介绍： The American Journal of Medicine - "The Green Journal" - publishes original clinical research of interest to physicians in internal medicine, both in academia and community-based practice. AJM is the official journal of the Alliance for Academic Internal Medicine, a prestigious group comprising internal medicine department chairs at more than 125 medical schools across the U.S. Each issue carries useful reviews as well as seminal articles of immediate interest to the practicing physician, including peer-reviewed, original scientific studies that have direct clinical significance and position papers on health care issues, medical education, and public policy.