Prevalence of hepatitis B virus surface antigen, associated risk factors, and liver enzyme abnormalities among individuals with diabetes in Aksum town public hospitals, Tigray, northern Ethiopia.

IF 0.9 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Pan African Medical Journal Pub Date : 2024-09-04 eCollection Date: 2024-01-01 DOI:10.11604/pamj.2024.49.6.43263
Mengstab Teklehaymanot Gebrelibanos, Krishna Chaithanya Karri, Tuem Gebre Abraha, Hailay Gebreyesus, Haftom Hadush Kidane, Mebrahtu Teweldemedhin Shfare
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引用次数: 0

Abstract

Introduction: hepatitis is an inflammatory disease of the liver; it is a major threat to public health and is more prevalent worldwide. Hepatitis B virus (HBV) is the leading cause of cirrhosis and hepatocellular carcinoma (HCC) with increasing mortality and burden of disease particularly in Asia and sub-Saharan Africa. Therefore, this study intended to assess the prevalence of HBsAg, associated risk factors, and liver enzyme abnormalities among individuals with diabetes mellitus (DM) in Aksum town public hospitals, Tigray, northern Ethiopia.

Methods: a hospital-based cross-sectional study was conducted among 359 randomly selected individuals with diabetes mellitus in public hospitals of Aksum town from February 10 to May 10, 2021. A pre-tested structured questionnaire was used to collect the data. Data was entered into Epi-Data version 3.1 and analysis was made using the statistical software SPSS version 21 for Windows. Bivariate and multivariate Logistic regression model was applied to show association between the dependent and independent variables; P <0.05 and 95% confidence interval was considered for statistical significance.

Results: in this study, 359 individuals with DM were included with a mean age (mean ± SD) of 46.44 ±16.58 years. The percentage of female participants was 44.3% (159/359). The prevalence of HBsAg among individuals with diabetes mellitus in Aksum town public hospitals was 12.8% (95% CI:8.9-17.0%). The associated risk factors were being employed [AOR:13.38, 95% CI 2.79-64.11; p<0.05], having history of multiple sexual partner [AOR:3.49, 95% CI 1.33-9.12; p<0.05], having history of body incision or piercing [AOR:3.80, 95% CI 1.12-12.90; p<0.05], liver enzyme abnormalities [AOR:6.90, 95% CI 2.17-21.94; p<0.005], and being single and widowed in marital status [AOR:4.42, 95% CI1.62-12.07; p<0.05].

Conclusion: based on the HBsAg positivity, the prevalence of HBV among individuals with diabetes mellitus in this study area was high, as compared to the national findings. Therefore, integrated efforts should be made at the community and health facility level to raise awareness of the associated risk factors, and reduce the spread of HBV; targeted screening of HBV among people with diabetes is also important to minimize liver abnormalities.

埃塞俄比亚北部提格雷州阿克苏姆镇公立医院中糖尿病患者的乙型肝炎病毒表面抗原流行率、相关风险因素和肝酶异常。
导言:肝炎是一种肝脏炎症性疾病;它是公共健康的主要威胁,在全球范围内发病率较高。乙型肝炎病毒(HBV)是导致肝硬化和肝细胞癌(HCC)的主要原因,特别是在亚洲和撒哈拉以南非洲地区,其死亡率和疾病负担不断增加。因此,本研究旨在评估埃塞俄比亚北部提格雷州阿克苏姆镇公立医院中糖尿病(DM)患者的 HBsAg 感染率、相关风险因素和肝酶异常。方法:2021 年 2 月 10 日至 5 月 10 日,本研究在阿克苏姆镇公立医院随机抽取的 359 名糖尿病患者中开展了一项基于医院的横断面研究。研究采用了一份预先测试过的结构化问卷来收集数据。数据被输入 Epi-Data 3.1 版,并使用 Windows 版 SPSS 21 统计软件进行分析。应用二元和多元 Logistic 回归模型显示因变量和自变量之间的关联;P 结果:本研究共纳入 359 名糖尿病患者,平均年龄(平均±标清)为 46.44±16.58 岁。女性参与者占 44.3%(159/359)。阿克苏姆镇公立医院糖尿病患者的 HBsAg 感染率为 12.8%(95% CI:8.9-17.0%)。相关的风险因素为就业[AOR:13.38, 95% CI 2.79-64.11; p结论:根据 HBsAg 阳性率,与全国调查结果相比,该研究地区糖尿病患者的 HBV 感染率较高。因此,应在社区和医疗机构层面做出综合努力,提高对相关风险因素的认识,减少 HBV 的传播;在糖尿病患者中开展有针对性的 HBV 筛查,对减少肝脏异常也很重要。
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来源期刊
Pan African Medical Journal
Pan African Medical Journal PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
1.80
自引率
0.00%
发文量
691
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