A rare case of aggressive uterine leiomyosarcoma: a case report.

IF 0.9 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Pan African Medical Journal Pub Date : 2024-09-09 eCollection Date: 2024-01-01 DOI:10.11604/pamj.2024.49.10.42105
Subrata Das, Srishti Srivastava, Pragati Srivastava, Nisha Prasad, Madhurima Roy, Inisha Sarkar
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引用次数: 0

Abstract

Uterine leiomyosarcoma is a rare aggressive uterine malignancy that arises from a smooth muscle of the uterus which accounts for 2-5% of all uterine malignancies. Definitive treatment is surgery with a high rate of recurrences. Our patient presented with lower abdominal pain and mass per abdomen which was diagnosed to be uterine leiomyosarcoma. A 56-year-old woman of East Indian origin presented with abdominal pain and a huge rapidly growing suprapubic abdominal mass with an almost monthly doubling. Her CA 125 and Lactate dehydrogenase (LDH) level was elevated and Computed Tomography (CT) scan showed a large irregular-shaped abdominopelvic solid heterogeneously enhanced lesion with focal central hyperdensity and areas of necrosis causing mass effect. A primary cytoreductive surgery was performed and the histopathology report confirmed the diagnosis of uterine leiomyosarcoma. A combination chemotherapy of six cycles was given to prevent recurrence. No recurrence was detected during her more than two years follow-up period. As the cases are rare in nature, screening is impractical. Hence, the diagnosis of uterine leiomyosarcoma is done by histopathologic examination after surgery.

一例罕见的侵袭性子宫良性肌瘤:病例报告。
子宫平滑肌肉瘤是一种罕见的侵袭性子宫恶性肿瘤,它产生于子宫平滑肌,占所有子宫恶性肿瘤的 2-5%。确定性治疗是手术,但复发率很高。我们的患者因下腹疼痛和腹部肿块就诊,经诊断为子宫肌层肉瘤。一名 56 岁的东印度妇女因腹痛和巨大的快速增长的耻骨上腹部肿块就诊,肿块几乎每月翻一番。她的CA 125和乳酸脱氢酶(LDH)水平升高,计算机断层扫描(CT)显示腹盆腔巨大不规则实性异质强化病灶,病灶中央密度增高,并有坏死区域,造成肿块效应。患者接受了一次细胞减灭术,组织病理学报告确诊为子宫卵母细胞肉瘤。为了防止复发,她接受了六个周期的联合化疗。在两年多的随访期间,没有发现复发。由于这种病例非常罕见,筛查并不现实。因此,子宫良性肌瘤的诊断需要在手术后进行组织病理学检查。
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来源期刊
Pan African Medical Journal
Pan African Medical Journal PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
1.80
自引率
0.00%
发文量
691
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