Relationship Between Cytokines and Face Skin Symptoms in Newborns in Two Japanese Cities.

IF 2 4区医学 Q3 DERMATOLOGY

Skin Research and Technology Pub Date : 2024-10-01 DOI:10.1111/srt.70098

Kaori Yonezawa, Sachi Higuchi, Satsuki Shimizu, Takeo Minematsu, Megumi Haruna

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引用次数: 0

Abstract

Aim: Several skin disorder symptoms may appear in infants, each resulting from a different inflammatory response. In this study, we investigated the relationship between skin cytokine levels and skin symptoms in newborns.

Methods: This cross-sectional study was conducted in Tokyo and Oita, two Japanese cities. The participants were healthy, 1-month-old infants and their parents. Symptoms including erythema, papules, dryness, and exudate/yellow scaling on infant faces were evaluated as outcomes. Cytokine levels (interleukin [IL]-4, IL-6, IL-8, and IL-17) were measured by skin blotting. A multilevel analysis using a mixed-effects model was conducted to account for regional differences.

Results: A total of 231 infants (119 from Tokyo and 112 from Oita) participated in this study. Erythema, papules, dryness, and exudate/yellow scaling were present in 59 (25.5%), 133 (57.6%), 37 (16.0%), and 16 (6.9%) of the infants, respectively. In terms of the associations between symptoms and cytokines, there was a significant association between papules and IL-8 positivity (adjusted odds ratio [AOR]: 1.94, 95% confidence interval [CI] 1.09-3.47) even after adjustment for differences in barrier function, area, and skin care.

Conclusions: This study demonstrated that cytokines were linked to skin conditions, even after accounting for regional differences and genetic factors. This suggests that different symptoms point to the involvement of various cytokines in skin conditions in neonates, with mechanisms varying based on the symptoms. These findings could aid in developing specific preventive strategies in the future.

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日本两个城市新生儿细胞因子与面部皮肤症状的关系

目的：婴儿可能会出现多种皮肤病症状，每种症状都是由不同的炎症反应引起的。本研究调查了新生儿皮肤细胞因子水平与皮肤症状之间的关系：这项横断面研究在东京和大分这两个日本城市进行。研究对象为 1 个月大的健康婴儿及其父母。研究结果评估了婴儿面部的红斑、丘疹、干燥和渗出物/黄色鳞屑等症状。细胞因子水平（白细胞介素 [IL]-4、IL-6、IL-8 和 IL-17）通过皮肤印迹法进行测量。使用混合效应模型进行了多层次分析，以考虑地区差异：共有 231 名婴儿（119 名来自东京，112 名来自大分县）参加了此次研究。分别有59名（25.5%）、133名（57.6%）、37名（16.0%）和16名（6.9%）婴儿出现红斑、丘疹、干燥和渗出/黄色鳞屑。就症状与细胞因子之间的关联而言，即使在调整了屏障功能、面积和皮肤护理的差异后，丘疹与 IL-8 阳性之间仍存在显著关联（调整赔率 [AOR]：1.94，95% 置信区间 [CI]：1.09-3.47）：本研究表明，即使考虑了地区差异和遗传因素，细胞因子仍与皮肤状况有关。这表明，不同的症状表明各种细胞因子与新生儿的皮肤状况有关，其机制也因症状而异。这些发现有助于今后制定具体的预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Skin Research and Technology 医学-皮肤病学

CiteScore

3.30

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.