Novel temperature responsive polymer based sealant for embolization.

IF 7.4 3区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Science and Technology of Advanced Materials Pub Date : 2024-09-25 eCollection Date: 2024-01-01 DOI:10.1080/14686996.2024.2409059

Ali E Dabiri, Ravin Narain, Yi-Yang Peng, Wenda Wang, Max Itkins, Ghassan S Kassab

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引用次数: 0

Abstract

A sealant has been developed that improves upon current catheter-based treatments in the following ways: 1) Efficient delivery system, 2) No in situ polymerization, 3) No harmful byproducts, and 4) Cost-effective formulation. During the development process, particular attention was given to materials that were tunable, safe, and effective sealant agents. The thermo-responsive properties of poly(N-isopropylacrylamide) (PNIPAM) provides an ideal foundation to develop an optimized solution. Through a combination of model-based and material testing, a hydrogel was developed that balances conformational factors to achieve a customized transition temperature, radiopacity suitable for visualization, mechanical properties suitable for delivery via 3Fr catheter, sufficient cohesion once applied to resist migration under physiological pressures and an improved safety profile. Two applications, embolization of lymphatic leakage and exclusions of the left atrial appendage (LAA), to eliminate LAA dead space to reduce the risk of thromboembolic events, were considered. The material and benchtop results for this product demonstrate the suitability of this new material not only for these applications but also for other potential healthcare applications.

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用于栓塞的新型温度响应聚合物密封剂。

现已开发出一种密封剂，它在以下方面改进了目前基于导管的治疗方法：1) 高效输送系统；2) 无需原位聚合；3) 无有害副产品；4) 成本效益高的配方。在开发过程中，我们特别关注可调、安全和有效的密封剂材料。聚（N-异丙基丙烯酰胺）（PNIPAM）的热响应特性为开发优化解决方案提供了理想的基础。通过模型测试和材料测试相结合的方法，开发出了一种水凝胶，这种水凝胶平衡了构象因素，可达到定制的过渡温度、适合可视化的放射性、适合通过 3Fr 导管输送的机械性能、应用后足够的内聚力以抵抗生理压力下的迁移，并提高了安全性。研究考虑了两种应用，即栓塞淋巴渗漏和排除左心房阑尾（LAA），以消除 LAA 死腔，降低血栓栓塞事件的风险。该产品的材料和台式结果表明，这种新材料不仅适用于这些应用，还适用于其他潜在的医疗保健应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science and Technology of Advanced Materials 工程技术-材料科学：综合

CiteScore

10.60

自引率

3.60%

发文量

审稿时长

4.8 months

期刊介绍： Science and Technology of Advanced Materials (STAM) is a leading open access, international journal for outstanding research articles across all aspects of materials science. Our audience is the international community across the disciplines of materials science, physics, chemistry, biology as well as engineering. The journal covers a broad spectrum of topics including functional and structural materials, synthesis and processing, theoretical analyses, characterization and properties of materials. Emphasis is placed on the interdisciplinary nature of materials science and issues at the forefront of the field, such as energy and environmental issues, as well as medical and bioengineering applications. Of particular interest are research papers on the following topics: Materials informatics and materials genomics Materials for 3D printing and additive manufacturing Nanostructured/nanoscale materials and nanodevices Bio-inspired, biomedical, and biological materials; nanomedicine, and novel technologies for clinical and medical applications Materials for energy and environment, next-generation photovoltaics, and green technologies Advanced structural materials, materials for extreme conditions.