Three new coumarins from Notopterygium incisum with potential anti-inflammatory activity.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-10-07 DOI:10.1080/10286020.2024.2411704

Xue-Yan Huo, Meng-Dan Liu, Yu-Hui Chen, Yun-Jie Hu, Chen-Yi Yan, Da-Le Guo, Yu-Cheng Gu, Li-Jun Huang, Yun Deng

引用次数: 0

Abstract

Three previously undescribed coumarins (1-3) were obtained from the roots of Notopterygium incisum. Their chemical structures were elucidated using a variety of spectroscopic techniques and chemical calculations. The inhibitory effects of these new compounds on NO production and pro-inflammatory factors (IL-1β, IL-6, and TNF-α) in LPS-stimulated RAW 264.7 cells were investigated. Further studies revealed that compound 1 suppressed the expression of COX-2 and iNOS while also reduced ROS accumulation. Western blot analysis demonstrated that compound 1 could inhibit the PI3K/AKT pathway by decreasing the levels of p-PI3K and p-AKT. Collectively, these findings suggest that compounds 1-3 exhibit promising anti-inflammatory properties.

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具有潜在抗炎活性的 Notopterygium incisum 中的三种新香豆素。

从 Notopterygium incisum 的根部获得了三种以前未曾描述过的香豆素（1-3）。利用多种光谱技术和化学计算方法阐明了它们的化学结构。研究了这些新化合物对 LPS 刺激的 RAW 264.7 细胞中 NO 生成和促炎因子（IL-1β、IL-6 和 TNF-α）的抑制作用。进一步研究发现，化合物 1 抑制了 COX-2 和 iNOS 的表达，同时还减少了 ROS 的积累。Western 印迹分析表明，化合物 1 可通过降低 p-PI3K 和 p-AKT 的水平来抑制 PI3K/AKT 通路。总之，这些发现表明化合物 1-3 具有良好的抗炎特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.