Correlation Between Reduced IL-1β Levels in Acne Lesions and the Decrease in Acne Inflammatory Lesions Following Topical Vitamin D Administration: A Double-Blind Randomized Controlled Trial.
Nelly Herfina Dahlan, Irma Bernadette S Sitohang, Wresti Indriatmi, Heri Wibowo, Liani Elisabeth Enggy
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引用次数: 0
Abstract
Background: The inflammatory process in acne vulgaris (AV) is characterized by the upregulation of specific pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, and IL-8, within sebocytes and keratinocytes. Sebocytes have been identified as target cells for bioactive vitamin D. Experimental studies on animal models have demonstrated the potent comedolytic effects of topical vitamin D. However, further research is required to specifically evaluate the impact of vitamin D on inflammatory lesions in acne vulgaris (AV).
Objective: To evaluate the effectiveness of topical vitamin D in treating acne vulgaris (AV) lesions by investigating its anti-inflammatory effects on pro-inflammatory cytokine modulation, specifically assessing the correlation between IL-1β levels in acne lesions and the reduction in AV severity.
Materials and methods: This study is a double-blind, randomized, placebo-controlled clinical trial with a 2-arm design over an 8-week intervention period. Participants were randomly assigned to either the topical vitamin D group (cholecalciferol 50 mcg) or the topical placebo group, with each group comprising 32 subjects. All participants received concomitant treatment with topical adapalene 0.1%. Cytokine levels within acne lesions were assessed using Luminex Polystyrene Screening Assays to detect and quantify IL-1β levels. The effectiveness of the treatment was evaluated by monitoring the reduction in the number of inflammatory lesions, while the safety of topical vitamin D was assessed by documenting and analyzing any reported side effects.
Results: The study found a significant correlation between the reduction in IL-1β levels within acne lesions and the decrease in moderate and severe inflammatory lesions in acne vulgaris (p = 0.028). The topical application of vitamin D led to a significant reduction in inflammatory AV lesions (p = 0.045). No significant topical side effects were observed in either the vitamin D or placebo groups.
Conclusion: This study demonstrates that the topical administration of vitamin D in acne vulgaris (AV) lesions is effective in reducing pro-inflammatory cytokine levels within acne lesions and in decreasing the severity of AV.
Trial registration: NCT05758259. September 5, 2022.
局部服用维生素 D 后痤疮皮损中 IL-1β 水平降低与痤疮炎症皮损减少之间的相关性：双盲随机对照试验》。
背景：寻常型痤疮（AV）炎症过程的特点是皮脂腺细胞和角质形成细胞内特定促炎细胞因子的上调，包括白细胞介素（IL）-1β、IL-6 和 IL-8。对动物模型的实验研究表明，外用维生素 D 具有强效的粉刺分解作用。然而，要具体评估维生素 D 对寻常性痤疮（AV）炎性病变的影响，还需要进一步的研究：评估外用维生素 D 对治疗寻常性痤疮（AV）皮损的效果，研究其对促炎细胞因子调节的抗炎作用，特别是评估痤疮皮损中 IL-1β 水平与减轻 AV 严重程度之间的相关性：本研究是一项双盲、随机、安慰剂对照临床试验，采用双臂设计，干预期为 8 周。参与者被随机分配到外用维生素 D 组（胆钙化醇 50 微克）或外用安慰剂组，每组 32 人。所有受试者均同时接受 0.1% 阿达帕林外用药治疗。痤疮皮损内的细胞因子水平通过 Luminex 聚苯乙烯筛查试剂盒进行评估，以检测和量化 IL-1β 的水平。通过监测炎症皮损数量的减少来评估治疗效果，同时通过记录和分析报告的任何副作用来评估外用维生素 D 的安全性：研究发现，痤疮皮损中 IL-1β 水平的降低与寻常型痤疮中度和重度炎症皮损的减少之间存在明显的相关性（p = 0.028）。外用维生素 D 能显著减少炎性 AV 病变（p = 0.045）。维生素 D 组和安慰剂组均未观察到明显的局部副作用：本研究表明，在寻常型痤疮（AV）皮损处局部使用维生素 D 可有效降低痤疮皮损内的促炎细胞因子水平，并减轻 AV 的严重程度：试验注册：NCT05758259。试验注册：NCT05758259。
期刊介绍：
Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal.
Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest.
The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care.
All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.
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