Aquaporin proteins: A promising frontier for therapeutic intervention in cerebral ischemic injury

IF 4.4 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2024-10-05 DOI:10.1016/j.cellsig.2024.111452

Ashi Mannan , Maneesh Mohan , Anshika Gulati , Sonia Dhiman , Thakur Gurjeet Singh

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引用次数: 0

Abstract

Cerebral ischemic injury is characterized by reduced blood flow to the brain, remains a significant cause of morbidity and mortality worldwide. Despite improvements in therapeutic approaches, there is an urgent need to identify new targets to lessen the effects of ischemic stroke. Aquaporins, a family of water channel proteins, have recently come to light as promising candidates for therapeutic intervention in cerebral ischemic injury. There are 13 aquaporins identified, and AQP4 has been thoroughly involved with cerebral ischemia as it has been reported that modulation of AQP4 activity can offers a possible pathway for therapeutic intervention along with their role in pH, osmosis, ions, and the blood-brain barrier (BBB) as possible therapeutic targets for cerebral ischemia injury. The molecular pathways which can interacts with particular cellular pathways, participation in neuroinflammation, and possible interaction with additional proteins thought to be involved in the etiology of a stroke. Understanding these pathways offers crucial information on the diverse role of AQPs in cerebral ischemia, paving the door for the development of focused/targeted therapeutics.

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水蒸发蛋白：大脑缺血损伤治疗干预的前沿领域。

脑缺血损伤的特点是脑部血流量减少，仍然是全球发病率和死亡率的重要原因。尽管治疗方法有所改进，但仍迫切需要找到新的靶点来减轻缺血性中风的影响。水通道蛋白家族中的水蒸发蛋白最近被发现有望成为治疗脑缺血损伤的候选靶点。目前已确定的水通道蛋白有 13 种，其中 AQP4 与脑缺血有密切关系，因为有报道称，调节 AQP4 的活性可为治疗干预提供一种可能的途径，同时它们在 pH 值、渗透、离子和血脑屏障（BBB）中的作用也是脑缺血损伤的可能治疗靶点。这些分子通路可与特定的细胞通路相互作用，参与神经炎症，并可能与其他被认为与中风病因有关的蛋白质相互作用。了解这些通路为了解 AQPs 在脑缺血中的不同作用提供了重要信息，为开发重点/靶向疗法铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.