Mitochondria in tumor immune surveillance and tumor therapies targeting mitochondria.

IF 6.6 2区医学 Q1 Medicine

Cellular Oncology Pub Date : 2024-10-07 DOI:10.1007/s13402-024-01000-1

Lvyuan Li, Yi Zhang, Qiling Tang, Chunyu Wu, Mei Yang, Yan Hu, Zhaojian Gong, Lei Shi, Can Guo, Zhaoyang Zeng, Pan Chen, Wei Xiong

引用次数: 0

Abstract

Mitochondria play a central role in cellular energy production and metabolic regulation, and their function has been identified as a key factor influencing tumor immune responses. This review provides a comprehensive overview of the latest advancements in understanding the role of mitochondria in tumor immune surveillance, covering both innate and adaptive immune responses. Specifically, it outlines how mitochondria influence the function of the tumor immune system, underscoring their crucial role in modulating immune cell behavior to either promote or inhibit tumor development and progression. Additionally, this review highlights emerging drug interventions targeting mitochondria, including novel small molecules with significant potential in cancer therapy. Through an in-depth analysis, it explores how these innovative strategies could improve the efficacy and outlook of tumor treatment.

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肿瘤免疫监视中的线粒体和针对线粒体的肿瘤疗法。

线粒体在细胞能量产生和代谢调节中发挥着核心作用，其功能已被确定为影响肿瘤免疫反应的关键因素。本综述全面概述了在了解线粒体在肿瘤免疫监视中的作用方面取得的最新进展，包括先天性免疫反应和适应性免疫反应。具体来说，它概述了线粒体如何影响肿瘤免疫系统的功能，强调了线粒体在调节免疫细胞行为以促进或抑制肿瘤发生和发展方面的关键作用。此外，这篇综述还重点介绍了针对线粒体的新兴药物干预措施，包括在癌症治疗中具有巨大潜力的新型小分子药物。通过深入分析，本综述探讨了这些创新策略如何改善肿瘤治疗的疗效和前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

10.40

自引率

1.50%

发文量

审稿时长

16 weeks

期刊介绍： The Official Journal of the International Society for Cellular Oncology Focuses on translational research Addresses the conversion of cell biology to clinical applications Cellular Oncology publishes scientific contributions from various biomedical and clinical disciplines involved in basic and translational cancer research on the cell and tissue level, technical and bioinformatics developments in this area, and clinical applications. This includes a variety of fields like genome technology, micro-arrays and other high-throughput techniques, genomic instability, SNP, DNA methylation, signaling pathways, DNA organization, (sub)microscopic imaging, proteomics, bioinformatics, functional effects of genomics, drug design and development, molecular diagnostics and targeted cancer therapies, genotype-phenotype interactions. A major goal is to translate the latest developments in these fields from the research laboratory into routine patient management. To this end Cellular Oncology forms a platform of scientific information exchange between molecular biologists and geneticists, technical developers, pathologists, (medical) oncologists and other clinicians involved in the management of cancer patients. In vitro studies are preferentially supported by validations in tumor tissue with clinicopathological associations.