Impact of Glutamine-Enhanced Parenteral Nutrition on Postoperative Outcomes in Colorectal Cancer Patients.

IF 2.5 4区医学 Q3 ONCOLOGY

Cancer Management and Research Pub Date : 2024-10-02 eCollection Date: 2024-01-01 DOI:10.2147/CMAR.S476648

Yong Huang, Chunmei Yin, Jue Wang, Maijian Wang, Xingbin Zheng, Ming Xie, Jiwei Wang

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引用次数: 0

Abstract

Purpose: This study investigated the effects of parenteral glutamine (Gln) supplement immunonutrition versus conventional nutritional support on postoperative Clavien-Dindo classification complications and recovery, perioperative nutritional status, and immune, inflammation, and safety indicators in patients with colorectal cancer (CRC).

Patients and methods: Clinical data were collected for a retrospective cohort study of 178 patients (58 and 120 patients in the observation and control groups, respectively) who underwent radical resection of CRC from January 2019 to December 2021. The incidence of postoperative complications was calculated. Postoperative recovery, nutritional indicators, inflammatory factors indicator, and the safety indicators before operation and at 1, 3, and 7 days after operation were compared. SPSS 29.0 statistical software was used for statistical analysis.

Results: The incidence of postoperative overall complications in the control group and the observation group was 22.50% (27/120) and 17.24% (10/58), respectively, and there was no significant difference between the two groups (P=0.42). The incidence of postoperative complications of Clavien-Dindo grade ≥III in the control group and the observation group was 14.17% (17/120) and 3.45% (2/58), respectively, and the difference between the two groups was statistically significant (P=0.03). Secondary outcomes (first exhaust, defecation, and liquid diet intake times) were significantly recovered earlier in the observation group than those in the control group (P<0.05), while the postoperative hospital stay was significantly shorter(P=0.04). The perioperative nutritional status did not significantly differ between the groups before and after surgery(P>0.05), although significant differences were observed in several inflammatory and safety indicators(P<0.05).

Conclusion: Unlike conventional nutritional support, postoperative parenteral Gln supplementation reduced the incidence of postoperative Clavien-Dindo complications grade ≥III in patients with CRC while increasing intestinal and immune functions, decreasing inflammation, and reducing the length of hospital stay.

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谷氨酰胺强化肠外营养对结直肠癌患者术后疗效的影响

目的：本研究调查了肠外谷氨酰胺（Gln）补充免疫营养与常规营养支持对结直肠癌（CRC）患者术后Clavien-Dindo分类并发症和恢复、围手术期营养状况以及免疫、炎症和安全指标的影响：一项回顾性队列研究收集了2019年1月至2021年12月期间接受CRC根治性切除术的178名患者（观察组和对照组分别有58名和120名患者）的临床数据。计算了术后并发症的发生率。比较术后恢复情况、营养指标、炎症因子指标以及术前和术后1、3、7天的安全性指标。统计分析采用 SPSS 29.0 统计软件：对照组和观察组的术后总并发症发生率分别为 22.50%（27/120）和 17.24%（10/58），两组差异无显著性（P=0.42）。对照组和观察组术后 Clavien-Dindo ≥III 级并发症的发生率分别为 14.17%（17/120）和 3.45%（2/58），两组间差异有统计学意义（P=0.03）。观察组的次要结果（首次排气、排便和流质饮食摄入时间）明显早于对照组（PP=0.04）。观察组和对照组在手术前后的围手术期营养状况没有明显差异（P>0.05），但在一些炎症和安全指标上有显著差异（PC结论：与传统的营养支持不同，术后家长营养支持是一种新的营养支持方式：与传统的营养支持不同，术后肠外补充 Gln 可降低 CRC 患者术后 Clavien-Dindo 并发症≥III 级的发生率，同时提高肠道和免疫功能，减少炎症，缩短住院时间。

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来源期刊

Cancer Management and Research Medicine-Oncology

CiteScore

7.40

自引率

0.00%

发文量

448

审稿时长

16 weeks

期刊介绍： Cancer Management and Research is an international, peer reviewed, open access journal focusing on cancer research and the optimal use of preventative and integrated treatment interventions to achieve improved outcomes, enhanced survival, and quality of life for cancer patients. Specific topics covered in the journal include: ◦Epidemiology, detection and screening ◦Cellular research and biomarkers ◦Identification of biotargets and agents with novel mechanisms of action ◦Optimal clinical use of existing anticancer agents, including combination therapies ◦Radiation and surgery ◦Palliative care ◦Patient adherence, quality of life, satisfaction The journal welcomes submitted papers covering original research, basic science, clinical & epidemiological studies, reviews & evaluations, guidelines, expert opinion and commentary, and case series that shed novel insights on a disease or disease subtype.