Clostridioides difficile toxin B suppresses human neutrophil migration

IF 2.5 3区生物学 Q3 MICROBIOLOGY

Anaerobe Pub Date : 2024-10-05 DOI:10.1016/j.anaerobe.2024.102916

Yoshitaka Kimura, Nami Hatayama, Yoshinori Sato, Yusuke Yoshino

引用次数: 0

Abstract

We investigated the effects of Clostridioides difficile toxin B (TcdB), a major virulence factor in C. difficile infection (CDI), on human neutrophils. TcdB inhibits neutrophil migration via loss of polarity of F-actin polymerization in response to interleukin-8. TcdB facilitates CDI by allowing C. difficile to avert the host immune system.

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艰难梭菌毒素 B 可抑制人类中性粒细胞迁移。

我们研究了艰难梭菌感染（CDI）的主要致病因子艰难梭菌毒素B（TcdB）对人类中性粒细胞的影响。在白细胞介素-8的作用下，TcdB通过F-肌动蛋白聚合极性的丧失抑制中性粒细胞的迁移。TcdB 可使艰难梭菌避开宿主免疫系统，从而促进艰难梭菌感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anaerobe 生物-微生物学

CiteScore

5.20

自引率

8.70%

发文量

137

审稿时长

76 days

期刊介绍： Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes. Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.