A Rare Case of Tirzepatide-Induced Hepatotoxicity.

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY

ACG Case Reports Journal Pub Date : 2024-10-04 eCollection Date: 2024-10-01 DOI:10.14309/crj.0000000000001484

Aalam Sohal, Luis Casanova, Kris V Kowdley

引用次数: 0

Abstract

Tirzepatide is the first dual incretin glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor activator approved for the management of type II diabetes mellitus. This drug was also recently approved by the Food and Drug Administration as a management option for patients with obesity. Tirzepatide has been also reported to be beneficial in reducing liver fat content. Although its efficacy is well described in the literature, no cases of tirzepatide-induced hepatotoxicity have been reported. We report a case of a 37-year-old woman with metabolic syndrome who was noted to have elevated liver enzymes secondary to tirzepatide use.

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一个罕见的地西泮诱发肝中毒病例

替扎帕肽是首个获准用于治疗 II 型糖尿病的葡萄糖依赖性促胰岛素多肽/胰高血糖素样肽 1 受体双增量素激活剂。最近，美国食品和药物管理局还批准将这种药物作为肥胖症患者的治疗选择。据报道，替西帕肽还有助于减少肝脏脂肪含量。虽然文献对其疗效进行了详细描述，但尚未有关于替扎帕肽诱发肝中毒的病例报道。我们报告了一例患有代谢综合征的 37 岁女性病例，她在服用替西帕肽后出现肝酶升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-

自引率

14.30%

发文量

170

审稿时长

12 weeks

期刊介绍： ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.