The Role of Interleukin-24 and Downstream Pathways in Inflammatory and Autoimmune Diseases.

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Biophysics Pub Date : 2024-10-07 DOI:10.1007/s12013-024-01576-3

Qiyun An, Xiaoyu Gu, Yuying Jiang

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引用次数: 0

Abstract

Inflammatory and autoimmune diseases are pathological immune disorders and pose significant public health challenges due to their impact on individuals and society. Cytokine dysregulation plays a critical role in the development of these disorders. Interleukin (IL)-24, a member of the IL-10 cytokine family, can be secreted by various cell types, including immune and non-immune cells. The downstream effects of IL-24 upon binding to its receptors can occur in dependence on, or independently of, the Janus kinase (JAK)/signal transducer and the activator of transcription (STAT) signaling pathway. IL-24 and its downstream pathways influence crucial processes such as cell differentiation, proliferation, apoptosis, and inflammation, with its role varying across different diseases. On the one hand, IL-24 can inhibit the activation of pathogenic cells and autoimmune responses in autoimmune ocular diseases; on the other hand, IL-24 has been also implicated in promoting tissue damage by fostering immune cell activation and infiltration in psoriasis and allergic diseases. It suggests that IL-24, as a multifunctional cytokine, has complex regulatory functions in immune cells and related diseases. In this paper, we summarize the current knowledge on IL-24's immunomodulatory actions and its involvement in inflammatory and autoimmune disorders. Such insights may pave the way for novel therapeutic strategies for these diseases.

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白细胞介素-24 及其下游通路在炎症和自身免疫性疾病中的作用

炎症性疾病和自身免疫性疾病是病理免疫紊乱，对个人和社会都有影响，对公共卫生构成重大挑战。细胞因子失调在这些疾病的发展中起着至关重要的作用。白细胞介素（IL）-24 是 IL-10 细胞因子家族的成员，可由各种细胞类型分泌，包括免疫细胞和非免疫细胞。IL-24与其受体结合后产生的下游效应可依赖于或独立于Janus激酶（JAK）/信号转导和转录激活因子（STAT）信号通路。IL-24 及其下游通路影响着细胞分化、增殖、凋亡和炎症等关键过程，其作用因疾病而异。一方面，在自身免疫性眼病中，IL-24 可抑制致病细胞的活化和自身免疫反应；另一方面，在银屑病和过敏性疾病中，IL-24 也被认为会促进免疫细胞的活化和浸润，从而造成组织损伤。这表明，IL-24 作为一种多功能细胞因子，在免疫细胞和相关疾病中具有复杂的调节功能。本文总结了目前有关 IL-24 免疫调节作用及其参与炎症和自身免疫性疾病的知识。这些见解可能为这些疾病的新型治疗策略铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

7.5 months

期刊介绍： Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized. Examples of subject areas that CBB publishes are: · biochemical and biophysical aspects of cell structure and function; · interactions of cells and their molecular/macromolecular constituents; · innovative developments in genetic and biomolecular engineering; · computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies; · photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.