Contents of sensitising rubber accelerators in disposable rubber gloves: A Copenhagen market survey.

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2024-10-05 DOI:10.1111/cod.14709

Christoffer Kursawe Larsen, Jakob F B Schwensen, Claus Zachariae, Cecilia Svedman, Jeanne D Johansen, Ola Bergendorff

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引用次数: 0

Abstract

Background: Rubber gloves contain rubber accelerators that may cause contact allergy. The content of sensitising rubber accelerators in contemporary rubber gloves is not well known.

Objectives: Identify and quantify the content of rubber accelerators in disposable rubber gloves.

Methods: Fifty-one gloves of 49 different brands were collected. Forty-eight of the gloves were disposable and three re-usable. The gloves were analysed for their content of sensitising rubber accelerators, that is, zinc dithiocarbamates, thiurams, thiazoles/benzothiazoles, diphenylguanidine, and thioureas by high-performance liquid chromatography.

Results: Rubber accelerators were identified in 43/48 (90%) of the disposable gloves. In total, 39 gloves contained zinc dibutyldithiocarbamate (ZDBC) (0.18-1.96 mg/g), 34 zinc diethyldithiocarbamate (ZDEC) (0.032-2.78 mg/g), three zinc dibenzyldithiocarbamate (0.65-1.4 mg/g), one zinc dimethyldithiocarbamate (0.23 mg/g), and one 1,3-diphenylguanidine (0.21 mg/g). 2-cyanoethyl dimethyldithiocarbamate (CEDMC) was identified in three gloves (<0.052 mg/g). The one glove labelled as accelerator free contained ZDBC (1.07 mg/g). Only few glove packages had the specific content of rubber accelerators labelled.

Conclusions: The most frequent rubber accelerators in rubber gloves are ZDEC and ZDBC. Accelerator-free gloves may contain rubber accelerators. Full labelling of rubber gloves is needed and producers should be sure not to falsely claim that the rubber gloves are free of rubber accelerators.

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一次性橡胶手套中的致敏橡胶促进剂含量：哥本哈根市场调查。

背景：橡胶手套中含有可能导致接触过敏的橡胶促进剂。人们对当代橡胶手套中致敏橡胶促进剂的含量知之甚少：确定并量化一次性橡胶手套中橡胶促进剂的含量：方法：收集了 49 种不同品牌的 51 只手套。方法：收集了 51 只 49 种不同品牌的手套，其中 48 只为一次性手套，3 只可重复使用。采用高效液相色谱法对手套中的致敏橡胶促进剂（即二硫代氨基甲酸锌、秋兰姆类、噻唑类/苯并噻唑类、二苯基胍类和硫脲类）含量进行分析：在 43/48 只（90%）一次性手套中发现了橡胶促进剂。共有 39 只手套含有二丁基二硫代氨基甲酸锌（ZDBC）（0.18-1.96 毫克/克），34 只含有二乙基二硫代氨基甲酸锌（ZDEC）（0.032-2.78 毫克/克），3 只含有二苄基二硫代氨基甲酸锌（0.65-1.4 毫克/克），1 只含有二甲基二硫代氨基甲酸锌（0.23 毫克/克），1 只含有 1,3-二苯基胍（0.21 毫克/克）。在三只手套中发现了 2-氰乙基二甲基二硫代氨基甲酸乙酯（CEDMC）（结论：CEDMC 是最常见的橡胶促进剂）：橡胶手套中最常见的橡胶促进剂是 ZDEC 和 ZDBC。不含促进剂的手套可能含有橡胶促进剂。需要对橡胶手套进行全面标识，生产商应确保不谎称橡胶手套不含橡胶促进剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".