Comparison of patch testing Brazilian (Green) propolis and Chinese (poplar-type) propolis: Clinical epidemiological study using data from the Information Network of Departments of Dermatology (IVDK).

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2024-10-05 DOI:10.1111/cod.14701

K Piontek, S Radonjic-Hoesli, J Grabbe, K P Drewitz, C Apfelbacher, S Wöhrl, D Simon, C Lang, S Schubert

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引用次数: 0

Abstract

Background: Propolis types differ regarding their chemical composition.

Objectives: To compare patch test results based on Brazilian (Green) propolis with data based on Chinese (poplar-type) propolis, and to evaluate the specifications of raw materials used for the PT preparations.

Methods: In the Information Network of Departments of Dermatology (IVDK), 1290 consecutive patients were patch tested with Brazilian (Green) propolis (NH400, SmartPractice Europe). Patch test reactivity was compared with results obtained with Chinese (poplar-type) propolis (NA71, SmartPractice Europe) by calculating frequencies and corresponding 95% confidence intervals. Data on the specifications of raw materials used for NH400 and NA71 were obtained from the manufacturer.

Results: Positive reactions to NH400 were found in 303 (23.5%) patients with unclear clinical relevance in most cases. Patients reacting to NH400 were less often sensitised to fragrances and colophony, but more often to nickel sulphate and cobalt chloride than patients reacting to NA71. The NH400 batch used contained high levels of aerobic bacteria, and was not purified by ethanolic extraction.

Conclusions: Pattern of concomitant reactivity along with raw material properties suggests that the high frequency of positive reactions to NH400 may primarily result from bacterial contamination or impurities in the PT preparation rather than from propolis constituents.

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巴西（绿色）蜂胶与中国（杨树型）蜂胶贴片测试的比较：利用皮肤科信息网络（IVDK）的数据进行临床流行病学研究。

背景：蜂胶的化学成分各不相同：比较巴西（绿色）蜂胶与中国（杨树型）蜂胶的斑贴试验结果，并评估PT制剂所用原材料的规格：在皮肤科信息网络（IVDK）中，连续对1290名患者进行了巴西（绿色）蜂胶（NH400，SmartPractice Europe）贴片测试。通过计算频率和相应的95%置信区间，将斑贴试验反应性与中国（杨树型）蜂胶（NA71，SmartPractice Europe）的结果进行比较。NH400和NA71所用原材料的规格数据来自生产商：303名（23.5%）患者对NH400产生了阳性反应，但大多数情况下临床相关性不明确。与对 NA71 过敏的患者相比，对 NH400 过敏的患者对香料和菌落总数过敏的较少，但对硫酸镍和氯化钴过敏的较多。所使用的 NH400 批次含有大量需氧细菌，而且没有经过乙醇提取纯化：结论：伴随反应的模式以及原材料的特性表明，NH400的高频率阳性反应可能主要是由于细菌污染或PT制剂中的杂质，而不是蜂胶成分造成的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".