The negative association between sodium-driven nutrient pattern and telomere length: the chain mediating role of diastolic pressure and waist circumference

IF 3.4 3区医学 Q2 GERIATRICS & GERONTOLOGY

Aging Clinical and Experimental Research Pub Date : 2024-10-05 DOI:10.1007/s40520-024-02852-1

Baodi Xing, Jie Yu, Yiwen Liu, Shuli He, Qi Gao, Xinyue Chen, Fan Ping, Lingling Xu, Wei Li, Huabing Zhang, Yuxiu Li

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引用次数: 0

Abstract

Background

Numerous single nutrients have been suggested to be linked with leukocyte telomere length (LTL). However, data on nutrient patterns (NPs), particularly in Chinese population, are scarce. This study aimed to examine the relationship between nutrient-based dietary patterns and LTL, and the potential role of metabolic factors.

Methods

Dietary data was obtained via 24-hour food recalls, and principal component analysis (PCA) was used to identify NPs. LTL was assessed using a real-time PCR assay. Multiple linear regression was conducted to determine the association between NPs and LTL. The potential role of metabolism among them was analyzed using mediation models.

Results

A total of 779 individuals from northern China were included in this cross-sectional analysis. Five main nutrient patterns were identified. Adjusted linear regression showed that the “high sodium” pattern was inversely associated with LTL (B=-0.481(-0.549, -0.413), P < 0.05). The “high vitamin E-fat” pattern exhibited a positive correlation (B = 0.099(0.029, 0.170), P < 0.05), whereas the “high vitamin A-vitamin B2” pattern was negatively correlated with LTL (B=-0.120(-0.183, -0.057), P < 0.05), respectively. No significant associations were observed for the remaining nutrient patterns. The mediation model demonstrated that diastolic blood pressure and waist circumference could individually and collectively mediate the negative impact of the “high sodium” pattern on LTL (B_DBP=-0.0173(-0.0333, -0.0041), B_WC=-0.0075(-0.0186, -0.0004), B_joint=-0.0033 (-0.0072, -0.0006), all P < 0.05). Moreover, glycosylated hemoglobin and non-high-density lipoprotein cholesterol mediate the relationship between the “high vitamin E-fat” pattern and LTL (B_HbA1c=0.0170(0.0010,0.0347), B_non-HDL-C= 0.0335 (0.0067, 0.0626), all P < 0.05), respectively.

Conclusions

The “high sodium” and “high vitamin E-fat” nutrient patterns demonstrated negative and positive associations with LTL and metabolic indicators may play complex mediating roles in these relationships.

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钠驱动的营养模式与端粒长度之间的负相关：舒张压和腰围的连锁中介作用。

背景：许多单一营养素被认为与白细胞端粒长度（LTL）有关。然而，有关营养素模式（NPs）的数据却很少，尤其是在中国人群中。本研究旨在探讨基于营养素的膳食模式与白细胞端粒长度之间的关系，以及代谢因素的潜在作用：方法：通过 24 小时食物回忆获得膳食数据，并使用主成分分析（PCA）确定营养素模式。采用实时 PCR 检测法评估低密度脂蛋白。采用多元线性回归法确定 NPs 与 LTL 之间的关系。使用中介模型分析了新陈代谢在其中的潜在作用：结果：这项横断面分析共纳入了来自中国北方的 779 人。确定了五种主要营养模式。调整后的线性回归显示，"高钠 "模式与LTL成反比（B=-0.481（-0.549，-0.413），P DBP=-0.0173（-0.0333，-0.0041），BWC=-0.0075（-0.0186，-0.0004），Bjoint=-0.0033（-0.0072，-0.0006），均 P HbA1c=0.0170（0.0010，0.0347），Bnon-HDL-C= 0.0335（0.0067，0.0626），均 P 结论：高钠 "和 "高维生素 E-脂肪 "营养模式与长期脂蛋白呈负相关和正相关，代谢指标可能在这些关系中起着复杂的中介作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Clinical and Experimental Research 医学-老年医学

CiteScore

7.90

自引率

5.00%

发文量

283

审稿时长

1 months

期刊介绍： Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.