Dietary quality and chemotherapy-induced peripheral neuropathy in colon cancer

IF 6.1 2区 医学 Q1 ONCOLOGY
Cancer Pub Date : 2024-10-05 DOI:10.1002/cncr.35599
Stephanie L. E. Compton PhD, RD, Shengping Yang PhD, Joseph Madere MApStat, Erin K. Weltzien BA, Bette J. Caan DrPH, Jeffrey A. Meyerhardt MD, MPH, Kathryn H. Schmitz PhD, MPH, Justin C. Brown PhD
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Abstract

Background

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting chemotoxicity caused by oxaliplatin. This study investigated the relationship between dietary quality and the development of moderate and/or severe CIPN in colon cancer survivors using data from the Focus on Reducing Dose-Limiting Toxicities in Colon Cancer with Resistance Exercise trial (ClinicalTrials.gov identifier NCT03291951).

Methods

Diet quality was collected using a 127-item food-frequency questionnaire and was scored using the Alternative Healthy Eating Index-2010 (AHEI-2010). CIPN was assessed with the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events at each chemotherapy cycle. The association of dietary quality with time to the first moderate-to-severe (moderate-severe) or severe event of CIPN was estimated using Cox proportional hazards models. Only participants who received oxaliplatin were included in this analysis (n = 132).

Results

Seventy-four participants (56.1%) reported moderate-severe CIPN. Higher dietary quality was associated with a significantly decreased risk of moderate-severe CIPN (hazard ratio [HR], 0.96; 95% confidence interval [CI], 0.93–0.99) and severe CIPN (HR, 0.91; 95% CI, 0.85–0.98). Consumption of red and processed meat (HR, 1.78; 95% CI, 1.07–2.83) and sugar-sweetened beverages (HR, 1.33; 95% CI, 1.10–1.59) was associated with an increased risk of moderate-severe CIPN. Consumption of sugar-sweetened beverages also was associated with an increased risk of severe CIPN (HR, 1.57; 95% CI, 1.14–2.18), whereas vegetable consumption was associated with a reduced risk of severe CIPN (HR, 0.29; 95% CI, 0.09–0.73).

Conclusions

Among patients with colon cancer who received oxaliplatin-based chemotherapy, higher baseline dietary quality was associated with a reduced risk of moderate-severe CIPN.

饮食质量与结肠癌化疗引起的周围神经病变
背景:化疗引起的周围神经病变(CIPN)是奥沙利铂引起的一种常见的剂量限制性化疗毒性。本研究利用 "通过阻力运动减轻结肠癌剂量限制性毒性 "试验(ClinicalTrials.gov identifier NCT03291951)的数据,调查了结肠癌幸存者的饮食质量与中度和/或重度 CIPN 发生之间的关系:采用 127 项食物频率调查问卷收集饮食质量,并采用替代性健康饮食指数-2010(AHEI-2010)进行评分。在每个化疗周期使用患者报告结果版不良事件通用术语标准对CIPN进行评估。采用 Cox 比例危险模型估算了饮食质量与首次中度至重度(中度至重度)或重度 CIPN 事件发生时间的关系。本分析仅包括接受奥沙利铂治疗的参与者(n = 132):结果:74 名参与者(56.1%)报告了中度-重度 CIPN。较高的饮食质量与中度-重度 CIPN(危险比 [HR],0.96;95% 置信区间 [CI],0.93-0.99)和重度 CIPN(HR,0.91;95% 置信区间 [CI],0.85-0.98)风险的显著降低有关。食用红肉和加工肉类(HR,1.78;95% CI,1.07-2.83)和含糖饮料(HR,1.33;95% CI,1.10-1.59)与中度-重度 CIPN 风险增加有关。饮用含糖饮料也与重度 CIPN 风险增加有关(HR,1.57;95% CI,1.14-2.18),而食用蔬菜与重度 CIPN 风险降低有关(HR,0.29;95% CI,0.09-0.73):结论:在接受奥沙利铂化疗的结肠癌患者中,较高的基线饮食质量与中度-重度CIPN风险的降低有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cancer
Cancer 医学-肿瘤学
CiteScore
13.10
自引率
3.20%
发文量
480
审稿时长
2-3 weeks
期刊介绍: The CANCER site is a full-text, electronic implementation of CANCER, an Interdisciplinary International Journal of the American Cancer Society, and CANCER CYTOPATHOLOGY, a Journal of the American Cancer Society. CANCER publishes interdisciplinary oncologic information according to, but not limited to, the following disease sites and disciplines: blood/bone marrow; breast disease; endocrine disorders; epidemiology; gastrointestinal tract; genitourinary disease; gynecologic oncology; head and neck disease; hepatobiliary tract; integrated medicine; lung disease; medical oncology; neuro-oncology; pathology radiation oncology; translational research
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