Yoshito Kadoya, Mehmet Onur Omaygenc, Benjamin Chow, Gary R. Small
{"title":"Reproducibility of myocardial extracellular volume quantification using dual-energy computed tomography in patients with cardiac amyloidosis","authors":"Yoshito Kadoya, Mehmet Onur Omaygenc, Benjamin Chow, Gary R. Small","doi":"10.1016/j.jcct.2024.09.011","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Quantifying myocardial extracellular volume (ECV) using computed tomography (CT) has been shown to be useful in the evaluation of cardiac amyloidosis. However, the reproducibility of CT measurements for myocardial ECV, is not well-established in patients with proven cardiac amyloidosis.</div></div><div><h3>Methods</h3><div>This prospective single-center study enrolled cardiac amyloidosis patients to undergo dual-energy CT for myocardial fibrosis assessment. Delayed imaging at 7 and 8 min post-contrast and independent evaluations by two blinded cardiologists were performed for ECV quantification using 16-segment (ECV<sub>global</sub>) and septal sampling (ECV<sub>septal</sub>). Inter- and intraobserver variability and test-retest reliability were measured using Spearman's rank correlation, Bland-Altman analysis, and intraclass correlation coefficients (ICC).</div></div><div><h3>Results</h3><div>Among the 24 participants (median age = 78, 67 % male), CT ECV<sub>global</sub> and ECV<sub>septal</sub> showed median values of 53.6 % and 49.1 % at 7 min, and 53.3 % and 50.1 % at 8 min, respectively. Inter- and intraobserver variability and test-retest reliability for CT ECV<sub>global</sub> (ICC = 0.798, 0.912, and 0.894, respectively) and ECV<sub>septal</sub> (ICC = 0.791, 0.898, and 0.852, respectively) indicated good reproducibility, with no evidence of systemic bias between observers or scans.</div></div><div><h3>Conclusions</h3><div>Dual-energy CT-derived ECV measurements demonstrated good reproducibility in patients with proven cardiac amyloidosis, suggesting potential utility as a repeatable imaging biomarker for this disease.</div></div>","PeriodicalId":49039,"journal":{"name":"Journal of Cardiovascular Computed Tomography","volume":"19 1","pages":"Pages 74-80"},"PeriodicalIF":5.5000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cardiovascular Computed Tomography","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1934592524004453","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Quantifying myocardial extracellular volume (ECV) using computed tomography (CT) has been shown to be useful in the evaluation of cardiac amyloidosis. However, the reproducibility of CT measurements for myocardial ECV, is not well-established in patients with proven cardiac amyloidosis.
Methods
This prospective single-center study enrolled cardiac amyloidosis patients to undergo dual-energy CT for myocardial fibrosis assessment. Delayed imaging at 7 and 8 min post-contrast and independent evaluations by two blinded cardiologists were performed for ECV quantification using 16-segment (ECVglobal) and septal sampling (ECVseptal). Inter- and intraobserver variability and test-retest reliability were measured using Spearman's rank correlation, Bland-Altman analysis, and intraclass correlation coefficients (ICC).
Results
Among the 24 participants (median age = 78, 67 % male), CT ECVglobal and ECVseptal showed median values of 53.6 % and 49.1 % at 7 min, and 53.3 % and 50.1 % at 8 min, respectively. Inter- and intraobserver variability and test-retest reliability for CT ECVglobal (ICC = 0.798, 0.912, and 0.894, respectively) and ECVseptal (ICC = 0.791, 0.898, and 0.852, respectively) indicated good reproducibility, with no evidence of systemic bias between observers or scans.
Conclusions
Dual-energy CT-derived ECV measurements demonstrated good reproducibility in patients with proven cardiac amyloidosis, suggesting potential utility as a repeatable imaging biomarker for this disease.
期刊介绍:
The Journal of Cardiovascular Computed Tomography is a unique peer-review journal that integrates the entire international cardiovascular CT community including cardiologist and radiologists, from basic to clinical academic researchers, to private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our cardiovascular imaging community across the world. The goal of the journal is to advance the field of cardiovascular CT as the leading cardiovascular CT journal, attracting seminal work in the field with rapid and timely dissemination in electronic and print media.