Effect of older age and/or ACL injury on the dose-response relationship between ambulatory load magnitude and immediate load-induced change in serum cartilage oligomeric matrix protein.

IF 9.7 1区医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM

Journal of Sport and Health Science Pub Date : 2024-10-04 DOI:10.1016/j.jshs.2024.100993

Simon Herger, Corina Nüesch, Anna-Maria Liphardt, Christian Egloff, Annegret Mündermann

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引用次数: 0

Abstract

Purpose: This study aimed to assess the influence of older vs. younger age and previous anterior cruciate ligament (ACL) injury on resting serum cartilage oligomeric matrix protein (sCOMP[t_pre]) concentration, on immediate load-induced sCOMP kinetics after a 30-min treadmill walking stress (∆_sCOMP[t_post]), and on the dose-response relationship between ambulatory load magnitude and ∆_sCOMP(t_post).

Methods: A total of 85 participants were recruited in 4 groups (20-30 years: 24 healthy, 23 ACL-injured; 40-60 years: 23 healthy, 15 ACL-injured). Blood samples were collected immediately before and after a walking stress at 80%, 100%, or 120% bodyweight (BW) on 3 test days and analyzed for sCOMP concentration. Linear models were used to estimate the effect of age, knee status (unilateral ACL injury, 2-10 years prior), and sex on sCOMP(t_pre), ∆_sCOMP(t_post)), and the dose-response between ambulatory load magnitude and ∆_sCOMP(t_post).

Results: We found that sCOMP(t_pre) was 21% higher in older than younger participants (p < 0.001) but did not differ between ACL-injured and healthy participants (p = 0.632). Also, ∆_sCOMP(t_post) was 19% lower in older than younger participants (p = 0.030) and increased with body mass index (p < 0.001), sCOMP(t_pre) (p = 0.008), and with 120%BW (p < 0.001), independent of age, ACL injury, or sex.

Conclusion: Age but not prior ACL injury influences resting sCOMP and load-induced sCOMP. The dose-response relationship between ambulatory load magnitude and load-induced sCOMP changes is not affected by age, ACL injury, or sex. A better understanding of systemic sCOMP and the role of its mechanoresponse for the understanding of osteoarthritis pathophysiology and monitoring intervention efficacy may require knowledge of individual cartilage composition and tissue-level loading parameters.

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高龄和/或十字韧带损伤对动态负荷大小与血清软骨低聚基质蛋白即时负荷诱导变化之间剂量-反应关系的影响。

目的：本研究旨在评估年龄较大与较小以及前交叉韧带（ACL）损伤对静息血清软骨寡聚基质蛋白（sCOMP(tpre)）浓度、30 分钟跑步机行走应力（Δ_sCOMP(tpost)）后即时负荷诱导的 sCOMP 动力学以及流动负荷大小与Δ_sCOMP(tpost)之间的剂量反应关系的影响：共招募了 85 名参与者，分为 4 组（20-30 岁：24 名健康者，23 名前交叉韧带损伤者；40-60 岁：23 名健康者，15 名前交叉韧带损伤者）。在3个测试日，分别在80%、100%或120%体重（BW）的步行压力前后采集血液样本，并分析其sCOMP浓度。我们使用线性模型估计了年龄、膝关节状况（单侧前交叉韧带损伤，2-10 年前）和性别对 sCOMP(tpre)、∆_sCOMP(tpost)的影响，以及流动负荷大小与 ∆_sCOMP(tpost) 之间的剂量反应：结果：我们发现，年龄较大的参与者的 sCOMP(tpre) 比年龄较小的参与者高 21%（p < 0.001），但前交叉韧带损伤者和健康参与者之间没有差异（p = 0.632）。此外，老年参与者的 ∆_sCOMP(tpost) 比年轻参与者低 19% (p = 0.030)，并随体重指数（p < 0.001）、sCOMP(tpre) （p = 0.008）和 120%BW （p < 0.001）的增加而增加，与年龄、前交叉韧带损伤或性别无关：结论：年龄而非前交叉韧带损伤会影响静息 sCOMP 和负荷诱导 sCOMP。动态负荷大小与负荷诱导的 sCOMP 变化之间的剂量反应关系不受年龄、前交叉韧带损伤或性别的影响。要想更好地了解全身sCOMP及其机械反应的作用，以了解骨关节炎的病理生理学并监测干预效果，可能需要了解个体软骨成分和组织级负荷参数。

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来源期刊

Journal of Sport and Health Science SPORT SCIENCES-

CiteScore

18.30

自引率

1.70%

发文量

101

审稿时长

22 weeks

期刊介绍： The Journal of Sport and Health Science (JSHS) is an international, multidisciplinary journal that aims to advance the fields of sport, exercise, physical activity, and health sciences. Published by Elsevier B.V. on behalf of Shanghai University of Sport, JSHS is dedicated to promoting original and impactful research, as well as topical reviews, editorials, opinions, and commentary papers. With a focus on physical and mental health, injury and disease prevention, traditional Chinese exercise, and human performance, JSHS offers a platform for scholars and researchers to share their findings and contribute to the advancement of these fields. Our journal is peer-reviewed, ensuring that all published works meet the highest academic standards. Supported by a carefully selected international editorial board, JSHS upholds impeccable integrity and provides an efficient publication platform. We invite submissions from scholars and researchers worldwide, and we are committed to disseminating insightful and influential research in the field of sport and health science.