The effects of green coffee bean extract on blood pressure and heart rate: A systematic review and dose-response meta-analysis of randomized controlled trials

IF 4.3 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-09-01 DOI:10.1016/j.dsx.2024.103120

Simin Samavat , Damoon Ashtary-Larky , Fatemeh Naeini , Behzad Nazarian , Sara Kashkooli , Cain C.T. Clark , Reza Bagheri , Omid Asbaghi , Maryam Babaali , Mohammad Ali Goudarzi , Ali Zamanian , Hadi Emamat

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引用次数: 0

Abstract

Background and aims

The existing literature on the effects of green coffee bean extract (GCBE) consumption on systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) is equivocal. This study aimed to summarize the effects of GCBE consumption on SBP, DBP and HR in adults.

Methods

Data were pooled using a random-effects model and expressed as weighted mean difference (WMD) and 95 % confidence intervals (95 % CIs).

Results

Out of 1624 records, 10 studies that enrolled 563 participants were included. GCBE consumption significantly decreased SBP (WMD: −2.95 mmHg; 95 % CI: −4.27 to −1.62; p < 0.001) and DBP (WMD: −2.15 mmHg; 95 % CI: −2.59 to −1.72; p < 0.001). However, there was no significant effect on HR (WMD: −1.20 bpm; CI: −2.93 to 0.51; p = 0.170). Subgroup analysis showed that GCBE consumption had a more significant effect on SBP and DBP in participants with high SBP and DBP and had no effect on blood pressure in females. Linear and non-linear dose-response analyses were conducted to find the optimum GCBE dosage and duration of intervention. However, no significant associations were observed for SBP, DBP, and HR in linear meta-regression and non-linear dose-response based on the dose and duration of the intervention.

Conclusion

GCBE has the potential as a hypertension-reducing supplement in hypertensive patients. However, GCBE did not significantly change HR.

查看原文本刊更多论文

绿咖啡豆提取物对血压和心率的影响：随机对照试验的系统回顾和剂量反应荟萃分析。

背景与目的：关于饮用绿咖啡豆提取物（GCBE）对收缩压（SBP）、舒张压（DBP）和心率（HR）影响的现有文献并不明确。本研究旨在总结服用 GCBE 对成人收缩压、舒张压和心率的影响：采用随机效应模型对数据进行汇总，并以加权平均差（WMD）和 95 % 置信区间（95 % CIs）表示：在1624条记录中，有10项研究纳入了563名参与者。服用五氯苯基醚可明显降低 SBP（WMD：-2.95 mmHg；95 % CI：-4.27 至-1.62；P 结论：五氯苯基醚具有作为高血压药物的潜力：谷胱甘肽具有降低高血压患者血压的潜力。然而，谷丙转氨酶对心率并无明显改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Metabolic Syndrome-Clinical Research & Reviews ENDOCRINOLOGY & METABOLISM-

CiteScore

22.90

自引率

2.00%

发文量

248

审稿时长

51 days

期刊介绍： Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.