Characterising delayed villous maturation: A narrative literature review

IF 3 2区医学 Q2 DEVELOPMENTAL BIOLOGY

Placenta Pub Date : 2024-10-01 DOI:10.1016/j.placenta.2024.09.020

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引用次数: 0

Abstract

The normal development of the placenta is vital for fetal growth and a healthy pregnancy outcome. Delayed villous maturation (DVM) is a placental lesion that has been implicated in stillbirth. In DVM, villi do not maturate adequately for their gestational age. DVM is characterised by larger and fewer terminal placental villi, low numbers of syncytial knots, and thicker and fewer vasculosyncytial membranes. DVM is most commonly reported in conjunction with maternal diabetes; however, the occurrence of idiopathic DVM suggests that there may be multiple mechanistic pathways that contribute to DVM. DVM can only be diagnosed through histopathological examination after birth, and there is significant interobserver variability in diagnosis. Establishing objective criteria to distinguish between DVM and healthy placentas is key to increasing the understanding of DVM. Vasculosyncytial membrane count, numbers of syncytial knots and CD15, among others, have been presented as potential diagnostic criteria in the literature. This review aims to compile information on DVM, including the pathophysiology, conditions that have reported associations with DVM and potential markers that could be used as criteria to differentiate between DVM and healthy placentas.

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绒毛成熟延迟的特征：文献综述

胎盘的正常发育对胎儿的生长和健康的妊娠结果至关重要。绒毛成熟延迟（DVM）是一种与死胎有关的胎盘病变。在 DVM 中，绒毛的成熟度与其胎龄不符。DVM的特征是胎盘末端绒毛变大、变少，合胞结数量少，血管合胞膜变厚、变少。胎盘早剥最常见的报道是与母体糖尿病同时发生；然而，特发性胎盘早剥的发生表明，可能有多种机制导致胎盘早剥。DVM 只能在婴儿出生后通过组织病理学检查确诊，而且在诊断过程中观察者之间的差异很大。建立区分DVM和健康胎盘的客观标准是提高对DVM认识的关键。文献中将血管鞘膜计数、鞘膜结数量和 CD15 等作为潜在的诊断标准。本综述旨在汇编有关DVM的信息，包括病理生理学、与DVM相关的病症以及可用作区分DVM和健康胎盘标准的潜在标记物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Placenta 医学-发育生物学

CiteScore

6.30

自引率

10.50%

发文量

391

审稿时长

78 days

期刊介绍： Placenta publishes high-quality original articles and invited topical reviews on all aspects of human and animal placentation, and the interactions between the mother, the placenta and fetal development. Topics covered include evolution, development, genetics and epigenetics, stem cells, metabolism, transport, immunology, pathology, pharmacology, cell and molecular biology, and developmental programming. The Editors welcome studies on implantation and the endometrium, comparative placentation, the uterine and umbilical circulations, the relationship between fetal and placental development, clinical aspects of altered placental development or function, the placental membranes, the influence of paternal factors on placental development or function, and the assessment of biomarkers of placental disorders.