Marilyn L Y Ong, Christopher G Green, Samantha N Rowland, Katie Rider, Harry Sutcliffe, Mark P Funnell, Andrea Salzano, Liam M Heaney
{"title":"Effect of an acute session of intermittent exercise on trimethylamine N-oxide (TMAO) production following choline ingestion.","authors":"Marilyn L Y Ong, Christopher G Green, Samantha N Rowland, Katie Rider, Harry Sutcliffe, Mark P Funnell, Andrea Salzano, Liam M Heaney","doi":"10.1007/s11306-024-02177-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Trimethylamine N-oxide (TMAO) is a gut bacteria-dependent metabolite associated with poor cardiovascular health. Exercise is a known cardioprotective activity but the impact of an acute bout of exercise on TMAO production is unknown.</p><p><strong>Objectives/methods: </strong>This study assessed choline-derived production of TMAO following a single bout of intermittent exercise in a young, healthy cohort.</p><p><strong>Results: </strong>Choline supplemented after either exercise or a time-matched resting period demonstrated a similar increase in circulating TMAO across an 8-hour period.</p><p><strong>Conclusion: </strong>This suggests that a single bout of intermittent exercise does not alter gut microbial metabolic behaviour and thus does not provide additional cardioprotective benefits related to blood levels of TMAO.</p>","PeriodicalId":18506,"journal":{"name":"Metabolomics","volume":"20 5","pages":"110"},"PeriodicalIF":3.5000,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455687/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Metabolomics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11306-024-02177-0","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Trimethylamine N-oxide (TMAO) is a gut bacteria-dependent metabolite associated with poor cardiovascular health. Exercise is a known cardioprotective activity but the impact of an acute bout of exercise on TMAO production is unknown.
Objectives/methods: This study assessed choline-derived production of TMAO following a single bout of intermittent exercise in a young, healthy cohort.
Results: Choline supplemented after either exercise or a time-matched resting period demonstrated a similar increase in circulating TMAO across an 8-hour period.
Conclusion: This suggests that a single bout of intermittent exercise does not alter gut microbial metabolic behaviour and thus does not provide additional cardioprotective benefits related to blood levels of TMAO.
期刊介绍：
Metabolomics publishes current research regarding the development of technology platforms for metabolomics. This includes, but is not limited to:
metabolomic applications within man, including pre-clinical and clinical
pharmacometabolomics for precision medicine
metabolic profiling and fingerprinting
metabolite target analysis
metabolomic applications within animals, plants and microbes
transcriptomics and proteomics in systems biology
Metabolomics is an indispensable platform for researchers using new post-genomics approaches, to discover networks and interactions between metabolites, pharmaceuticals, SNPs, proteins and more. Its articles go beyond the genome and metabolome, by including original clinical study material together with big data from new emerging technologies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
