Research on the causal relationship between fine particulate matter and type 2 diabetes mellitus: A two-sample multivariable mendelian randomization study

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-09-05 DOI:10.1016/j.numecd.2024.08.023

Xinyang Shou , Zhenghong Yao , Yimin Wang , Yanxi Chai , Yuxin Huang , Rucheng Chen , Weijia Gu , Qiang Liu

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引用次数: 0

Abstract

Background and aims

Previous research has suggested a correlation between fine particulate matter (PM2.5) and type 2 diabetes mellitus (T2DM). However, the causality was vulnerable to confounding variables.

Methods and results

A two-sample multivariable mendelian randomization study was designed to examine the causal connection between PM2.5 and T2DM. PM2.5 trait was investigated as exposure while T2DM-related traits as outcomes. The summary data were obtained from the Finngen database and the open genome-wide association study database. The mendelian randomization estimates were obtained using the inverse-variance weighted approach, and multiple sensitivity analyses were conducted. There were potential causal relationships between PM2.5 and T2DM (OR = 2.418; P = 0.019), PM2.5 and glycated hemoglobin (HbA1c) (OR = 1.590; P = 0.041), and PM2.5 and insulin metabolism. PM2.5 was found to have no causal effect on fasting glucose and insulin, 2-h glucose, and insulin-like growth factor binding protein-1 (P > 0.05), while had a potential protective effect against some diabetes complications.

Conclusions

Our findings indicated potential causal relationships among PM2.5 and T2DM, especially the causal relationship between PM2.5 and long-term glucose levels.

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细颗粒物与 2 型糖尿病因果关系研究：一项双样本多变量孟德尔随机研究。

背景和目的：以往的研究表明，细颗粒物（PM2.5）与2型糖尿病（T2DM）之间存在相关性。然而，这种因果关系很容易受到混杂变量的影响：我们设计了一项双样本多变量亡羊补牢随机研究，以检验 PM2.5 与 T2DM 之间的因果关系。PM2.5特质作为暴露因素，T2DM相关特质作为结果。摘要数据来自芬根数据库和开放的全基因组关联研究数据库。采用逆方差加权法获得了 "泯灭随机化 "估计值，并进行了多重敏感性分析。PM2.5与T2DM（OR = 2.418; P = 0.019）、PM2.5与糖化血红蛋白（HbA1c）（OR = 1.590; P = 0.041）以及PM2.5与胰岛素代谢之间存在潜在的因果关系。研究发现，PM2.5 对空腹血糖和胰岛素、2 小时血糖以及胰岛素样生长因子结合蛋白-1 没有因果关系（P > 0.05），但对某些糖尿病并发症有潜在的保护作用：我们的研究结果表明了 PM2.5 与 T2DM 之间的潜在因果关系，尤其是 PM2.5 与长期血糖水平之间的因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Metabolism and Cardiovascular Diseases 医学-内分泌学与代谢

CiteScore

6.80

自引率

2.60%

发文量

332

审稿时长

57 days

期刊介绍： Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.