Relationship between serum uric acid levels and pulmonary embolism: an age-based stratified analysis.

IF 2.6 4区医学 Q2 HEMATOLOGY

Thrombosis Journal Pub Date : 2024-10-04 DOI:10.1186/s12959-024-00655-y

Bin Yuan, Lingyue Song, Weiqing Su, Xianbing Zeng, Jinqiang Su, Jie Sun, Jun Wu, Kaili Fu, Zhihai Huang, Qiaoyun Chen, Dingyu Guo, Xishi Sun, Lingpin Pang

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引用次数: 0

Abstract

Background: The association between uric acid and pulmonary embolism(PE) remains controversial, and there has been limited investigation into how uric acid influences pulmonary embolism across different age groups. Our study aimed to elucidate the relationship between uric acid levels and pulmonary embolism, considering variations across age groups.

Methods: A total of 368 patients who underwent computed tomography pulmonary angiography from July 2018 to May 2022 were included in the analysis. Subsequently, the cohort was stratified by age, with separate univariate and multivariate logistic regression analyses conducted for the elderly (aged ≥ 60 years) and non-elderly (aged < 60 years), respectively.

Results: The study revealed that patients with PE exhibited higher uric acid levels compared to those without (325.11 ± 137.02 vs. 298.26 ± 110.54 (umol/l), p = 0.039). This disparity persisted even after adjusting for multiple confounders (OR = 1.002, 95% CI 1.000-1.005, p = 0.042). Additionally, a notable age difference was observed between PE and non-PE patients (65.7 ± 16.12 vs. 61.42 ± 15.03 (umol/l), p = 0.009). Subsequently, upon age stratification, significant differences (p < 0.05) in serum uric acid were noted between PE and non-PE patients in both elderly and non-elderly populations. However, elevated uric acid levels were independently associated with PE only in the elderly following adjustment for multiple confounders (OR = 1.003, 95% CI 1.001-1.005, p = 0.008).

Conclusion: High uric acid levels are an independent risk factor for pulmonary embolism in the elderly (≥ 60 years).

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血清尿酸水平与肺栓塞之间的关系：基于年龄的分层分析。

背景：尿酸与肺栓塞（PE）之间的关系仍存在争议，对尿酸如何影响不同年龄组肺栓塞的研究也很有限。我们的研究旨在阐明尿酸水平与肺栓塞之间的关系，同时考虑不同年龄组的差异：分析对象包括2018年7月至2022年5月期间接受计算机断层扫描肺动脉造影术的368名患者。随后，按年龄对队列进行分层，分别对老年人（年龄≥60 岁）和非老年人（年龄结果：结果显示，老年人和非老年人的肺动脉栓塞发生率均高于非老年人：研究显示，与非 PE 患者相比，PE 患者的尿酸水平更高（325.11 ± 137.02 vs. 298.26 ± 110.54（umol/l），p = 0.039）。即使在调整了多种混杂因素后，这一差异仍然存在（OR = 1.002，95% CI 1.000-1.005，p = 0.042）。此外，还观察到 PE 患者和非 PE 患者之间存在明显的年龄差异（65.7 ± 16.12 vs. 61.42 ± 15.03 (umol/l)，p = 0.009）。随后，对年龄进行分层后，发现两者之间存在显著差异（p 结论：高尿酸水平是一种独立的疾病：高尿酸水平是老年人（≥ 60 岁）肺栓塞的独立风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Thrombosis Journal Medicine-Hematology

CiteScore

3.80

自引率

3.20%

发文量

审稿时长

16 weeks

期刊介绍： Thrombosis Journal is an open-access journal that publishes original articles on aspects of clinical and basic research, new methodology, case reports and reviews in the areas of thrombosis. Topics of particular interest include the diagnosis of arterial and venous thrombosis, new antithrombotic treatments, new developments in the understanding, diagnosis and treatments of atherosclerotic vessel disease, relations between haemostasis and vascular disease, hypertension, diabetes, immunology and obesity.