Schsphenines A and B, two new lignans from the fruit of Schisandra sphenanthera with cardioprotective Activities.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-10-04 DOI:10.1080/14786419.2024.2410415

Jinyu Yu, Wen Yu, Xingan Wu, Jing Han

引用次数: 0

Abstract

Schsphenines A (1) and B (2), two new lignans were isolated from the fruit of Schisandra sphenanthera, together with six known ones respectively identified as schisanhenol (3), methylgomisin O (4), wuweilignan E (5), neglschisandrin E (6), schisandrin A (7) and schisandrin B (8). The structures of isolated compounds were determined by UV, IR, HR-ESI-MS, NMR, ORD analysis and quantum chemical calculation. The in vitro cardioprotective activities of all compounds were studied on H₂O₂-injury H9C2 cells using the MTT method. Compound 1 exhibited a considerable protective effect with cell viability in 79.94 ± 2.36%. This research provided useful information for the utilisation of S. sphenanthera as the TCM.

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五味子果实中具有心脏保护作用的两种新木质素--五味子素 A 和 B。

从五味子果实中分离出两种新的木脂素--五味子素 A（1）和 B（2），以及六种已知的木脂素，分别为五味子醇（3）、甲基五味子素 O（4）、五味子素 E（5）、五味子素 E（6）、五味子素 A（7）和五味子素 B（8）。通过紫外、红外、HR-ESI-MS、核磁共振、ORD 分析和量子化学计算确定了分离化合物的结构。采用 MTT 法研究了所有化合物对 H2O2 损伤的 H9C2 细胞的体外心脏保护活性。化合物 1 显示出相当大的保护作用，细胞存活率为 79.94 ± 2.36%。这项研究为将 S. sphenanthera 用作中药提供了有用的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.