Emerging evidence of a link between inflammation and the neuropathology of prenatal opioid exposure

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Opinion in Neurobiology Pub Date : 2024-10-03 DOI:10.1016/j.conb.2024.102924

Isobel A.R. Williams, Kelly J. Clemens

引用次数: 0

Abstract

Opioid use continues to increase, particularly among women of reproductive age. As a result, increasing numbers of infants are born with prenatal exposure to opioids, suffering both acute and long-term negative consequences. Studies performed across the past 5 years have highlighted both peripheral and central inflammation as a consistent feature of prenatal opioid exposure. Dysregulated innate and adaptive immunity have been detected in human and rodent studies, highlighting a likely role of inflammation in the neuropathology associated with opioid exposure. Identifying immune changes occurring following prenatal opioid exposure will be critical for developing new therapeutic approaches in this field.

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炎症与产前接触阿片类药物的神经病理学之间存在联系的新证据。

阿片类药物的使用持续增加，尤其是在育龄妇女中。因此，越来越多的婴儿在出生前接触到阿片类药物，并遭受急性和长期的负面影响。过去 5 年的研究强调，外周和中枢炎症是产前接触阿片类药物的一致特征。在人类和啮齿类动物的研究中发现了先天性和适应性免疫失调，这表明炎症可能在与接触阿片类药物有关的神经病理学中发挥作用。确定产前接触阿片类药物后发生的免疫变化对于在该领域开发新的治疗方法至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Neurobiology 医学-神经科学

CiteScore

11.10

自引率

1.80%

发文量

130

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience