Perturbing the line

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2024-10-04 DOI:10.1038/s41593-024-01779-0

Luis A. Mejia

引用次数: 0

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扰动线路

大脑可能利用连续吸引子动力学来编码与行为相关的变量，但仍然缺乏其电路级实现的直接证据。Vinograd 和 Nair 等人对正在观察其他小鼠之间攻击性相遇的小鼠下丘脑中的线性吸引子样神经动态进行了成像。有趣的是，全息光遗传激活吸引子贡献整合神经元会导致沿线吸引子的阶梯运动，而激活正交神经元则会导致瞬时的阶梯外扰动，随后放松进入吸引子。令人信服的是，单神经元刺激揭示了整合神经元之间的选择性功能连接，而线吸引子的稳定性（与攻击性的个体差异有关）与这些神经元集合内的功能连接程度相关。这些数据表明，连续吸引子动力学可能与哺乳动物的神经编码和最终行为有因果关系：自然 https://doi.org/10.1038/s41586-024-07915-x (2024)

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.