Biological Reference Ranges for Healthy Indian Blood Donors: Experience of a Tertiary Care Center Vis-à-Vis International Literature

IF 2.2 4区医学 Q3 HEMATOLOGY

International Journal of Laboratory Hematology Pub Date : 2024-10-04 DOI:10.1111/ijlh.14375

Shalini Goel, Aseem Kumar Tiwari, Pawan Kumar Gahlot, Manish Kumar Singh, Renu Saxena, Vaibhav Jadhav, Monisha Sethi, Tan Swee Jin

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Abstract

Introduction

Complete blood count is the most common, basic test requisitioned in hematology. The normal reference ranges of hematological parameters are required owing to variable socioeconomic, environmental, and genetic factors in populations. The current study determines the reference ranges of the healthy Indian donor population of a high socioeconomic group.

Methods

The study was conducted in the Department of Transfusion Medicine at a tertiary care hospital in India and included 4098 individuals, aged 18–65 years coming for voluntary blood donation from July 2021 to October 2022. Blood samples were collected in K2EDTA, analyzed on the Sysmex XN-1500 hematology analyzer, and using statistical tools, the normal reference ranges were calculated.

Results

The reference ranges for hemoglobin (HB) (137–185 g/L), WBC (5.1–11.7 × 10⁹/L), platelet count (115.6–370.0 × 10⁹/L) were noted. [Correction added on 22 10 2024, after first online publication: The WBC value has been corrected in this version.] No statistically significant changes were observed in different age groups. There were gender-wise differences noted in nearly all parameters. The HB and hematocrit (HCT) range was slightly higher in other Indian and other Asian populations with comparable values with the Chinese, Korean populations, and Western populations; RBC parameters were overall comparable with minor differences; the WBC count was higher than the other Indian and Asian populations particularly the upper limit of lymphocyte and monocyte; and the range of platelet counts had a comparable upper limit with all populations and had the lowest lower value in males in our study, which was comparable to only the Chinese population.

Conclusions

It is concluded that reference ranges of common parameters were calculated with minor changes noted in all hematological parameters on comparing with other Indian, Asian population, and Western data.

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印度健康献血者的生物参考范围：一家三级医疗中心的经验与国际文献的对比。

简介全血细胞计数是血液学中最常见、最基本的检测项目。由于不同人群的社会经济、环境和遗传因素各不相同，因此需要血液学参数的正常参考范围。本研究确定了社会经济地位较高的印度健康捐献者的参考范围：研究在印度一家三级医院的输血医学科进行，包括 4098 名从 2021 年 7 月至 2022 年 10 月自愿献血的 18-65 岁的人。血样用 K2EDTA 采集，在 Sysmex XN-31 血液分析仪上进行分析，并利用统计工具计算出正常参考范围：结果：血红蛋白（HB）（137-185 克/升）、白细胞（5.1-1.7×109/升）、血小板计数（115.6-370.0×109/升）的参考范围。在不同年龄组中未观察到有统计学意义的变化。几乎所有参数都存在性别差异。其他印度和其他亚洲人群的 HB 和血细胞比容（HCT）范围略高，与中国、韩国和西方人群的数值相当；红细胞参数总体相当，差异较小；白细胞计数高于其他印度和亚洲人群，尤其是淋巴细胞和单核细胞的上限；血小板计数范围的上限与所有人群相当，在我们的研究中，男性的血小板计数下限最低，仅与中国人群相当：结论：与其他印度人、亚洲人和西方人的数据相比，我们计算出了常见参数的参考范围，所有血液学参数的变化都很小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Laboratory Hematology 医学-血液学

CiteScore

4.50

自引率

6.70%

发文量

211

审稿时长

6-12 weeks

期刊介绍： The International Journal of Laboratory Hematology provides a forum for the communication of new developments, research topics and the practice of laboratory haematology. The journal publishes invited reviews, full length original articles, and correspondence. The International Journal of Laboratory Hematology is the official journal of the International Society for Laboratory Hematology, which addresses the following sub-disciplines: cellular analysis, flow cytometry, haemostasis and thrombosis, molecular diagnostics, haematology informatics, haemoglobinopathies, point of care testing, standards and guidelines. The journal was launched in 2006 as the successor to Clinical and Laboratory Hematology, which was first published in 1979. An active and positive editorial policy ensures that work of a high scientific standard is reported, in order to bridge the gap between practical and academic aspects of laboratory haematology.