Kathryn E Hopperton, Erica O'Neill, Subhadeep Chakrabarti, Melanie Stanton, Sophie Parnel, Tye E Arbuckle, Jillian Ashley-Martin, Jesse Bertinato, Maryse F Bouchard, Michael M Borghese, Stephen Brooks, Kevin Cockell, Robert Dabeka, Meong Jin Joung, Bruce P Lanphear, Pascal Lapointe, Amanda J MacFarlane, Susan MacPherson, John Krzeczkowski, Dorothea F K Rawn, Peter von Dadelszen, Hope A Weiler, Chao Wu Xiao, Mandy Fisher
{"title":"Concentrations and predictors of select nutrients in Canadian human milk samples from the MIREC pregnancy cohort.","authors":"Kathryn E Hopperton, Erica O'Neill, Subhadeep Chakrabarti, Melanie Stanton, Sophie Parnel, Tye E Arbuckle, Jillian Ashley-Martin, Jesse Bertinato, Maryse F Bouchard, Michael M Borghese, Stephen Brooks, Kevin Cockell, Robert Dabeka, Meong Jin Joung, Bruce P Lanphear, Pascal Lapointe, Amanda J MacFarlane, Susan MacPherson, John Krzeczkowski, Dorothea F K Rawn, Peter von Dadelszen, Hope A Weiler, Chao Wu Xiao, Mandy Fisher","doi":"10.1016/j.ajcnut.2024.09.029","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Human milk (HM) composition data are widely used in clinical, regulatory, and public health initiatives. The existing HM profiles in U.S. and Canadian nutrient databanks are outdated and now considered inappropriate to estimate current nutrient intakes. Recent reviews have underscored the limited North American data available to generate a new profile.</p><p><strong>Objective: </strong>To describe concentrations and sources of variability of nutrients in HM from a large cohort collected in Canada.</p><p><strong>Methods: </strong>The Maternal-Infant Research on Environmental Chemicals (MIREC) study recruited participants in the first trimester of pregnancy from 10 Canadian cities between 2008-2011. HM samples (n=559-835, depending on nutrient) were collected 3-10 weeks post-partum and analyzed for minerals (calcium, magnesium, phosphorus, potassium, sodium, manganese, molybdenum, zinc, copper, iodine, selenium), vitamin D (vitamin D<sub>3</sub>, 25-(OH)D<sub>3</sub>), folate vitamers (folic acid, 5-methyltetrahydrofolate, total folates), and fatty acids (panel). We examined associations between participant characteristics and log-transformed nutrient concentrations using linear regression.</p><p><strong>Results: </strong>Concentrations of HM components in MIREC samples were within the range observed in literature except for manganese, which was >100 fold lower than the value in the existing Canadian nutrient databank profile (2.43 [SD 2.84] compared to 260 ng/g). In multivariable models, concentrations of folate vitamers, vitamin D and fatty acids demonstrated greater variability with maternal and sample characteristics than minerals. Factors such as relevant supplement use, body mass index (BMI), and for vitamin D, skin color and season, had a larger impact on nutrient concentrations than characteristics typically standardized in HM research, such as maternal or infant health, and method of collection.</p><p><strong>Conclusion: </strong>HM mineral concentrations from this study meet the methodological inclusion criteria for updating nutrient databank values and dietary reference intakes. Consideration of factors such as diet, skin colour, and BMI will be important for selecting studies for developing representative reference values based on human milk.</p>","PeriodicalId":50813,"journal":{"name":"American Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":6.5000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Clinical Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ajcnut.2024.09.029","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Human milk (HM) composition data are widely used in clinical, regulatory, and public health initiatives. The existing HM profiles in U.S. and Canadian nutrient databanks are outdated and now considered inappropriate to estimate current nutrient intakes. Recent reviews have underscored the limited North American data available to generate a new profile.
Objective: To describe concentrations and sources of variability of nutrients in HM from a large cohort collected in Canada.
Methods: The Maternal-Infant Research on Environmental Chemicals (MIREC) study recruited participants in the first trimester of pregnancy from 10 Canadian cities between 2008-2011. HM samples (n=559-835, depending on nutrient) were collected 3-10 weeks post-partum and analyzed for minerals (calcium, magnesium, phosphorus, potassium, sodium, manganese, molybdenum, zinc, copper, iodine, selenium), vitamin D (vitamin D3, 25-(OH)D3), folate vitamers (folic acid, 5-methyltetrahydrofolate, total folates), and fatty acids (panel). We examined associations between participant characteristics and log-transformed nutrient concentrations using linear regression.
Results: Concentrations of HM components in MIREC samples were within the range observed in literature except for manganese, which was >100 fold lower than the value in the existing Canadian nutrient databank profile (2.43 [SD 2.84] compared to 260 ng/g). In multivariable models, concentrations of folate vitamers, vitamin D and fatty acids demonstrated greater variability with maternal and sample characteristics than minerals. Factors such as relevant supplement use, body mass index (BMI), and for vitamin D, skin color and season, had a larger impact on nutrient concentrations than characteristics typically standardized in HM research, such as maternal or infant health, and method of collection.
Conclusion: HM mineral concentrations from this study meet the methodological inclusion criteria for updating nutrient databank values and dietary reference intakes. Consideration of factors such as diet, skin colour, and BMI will be important for selecting studies for developing representative reference values based on human milk.
期刊介绍:
American Journal of Clinical Nutrition is recognized as the most highly rated peer-reviewed, primary research journal in nutrition and dietetics.It focuses on publishing the latest research on various topics in nutrition, including but not limited to obesity, vitamins and minerals, nutrition and disease, and energy metabolism.
Purpose:
The purpose of AJCN is to:
Publish original research studies relevant to human and clinical nutrition.
Consider well-controlled clinical studies describing scientific mechanisms, efficacy, and safety of dietary interventions in the context of disease prevention or health benefits.
Encourage public health and epidemiologic studies relevant to human nutrition.
Promote innovative investigations of nutritional questions employing epigenetic, genomic, proteomic, and metabolomic approaches.
Include solicited editorials, book reviews, solicited or unsolicited review articles, invited controversy position papers, and letters to the Editor related to prior AJCN articles.
Peer Review Process:
All submitted material with scientific content undergoes peer review by the Editors or their designees before acceptance for publication.