The impact of hepatitis B surface antigen seroconversion on the durability of functional cure induced by pegylated interferon alpha treatment.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-10-03 DOI:10.1186/s12985-024-02522-8

Wencong Zhang, Jia Chen, Wenjin Sun, Nana Xie, Fangbing Tian, Qiurong Ruan, Jianxin Song

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引用次数: 0

Abstract

Background: Hepatitis B surface antigen (HBsAg) loss is regarded as a pivotal criterion for assessing functional cure in patients diagnosed chronic hepatitis B (CHB). We conducted the research to investigate the real-world performance of HBsAg seroconversion in sustaining HBsAg loss.

Methods: This retrospective analysis confirmed 295 patients who attained HBsAg loss through combination therapy involving nucleos(t)ide analogues (NAs) and pegylated interferon alpha (peg-IFNα). Employing Kaplan-Meier estimates method to conduct survival analysis. The forest plot was used to visualize the results of multivariate Cox regression, and selected variables were included in the nomogram.

Results: HBsAg seroreversion was observed in 45 patients during follow-up periods, with a lower recurrence risk in patients with HBsAg seroconversion at the end of peg-IFNα therapy (EOT) (10.3% vs 37.3% at 96-week, P < 0.0001). Moreover, the sustainability of hepatitis B surface antibody (anti-HBs) in participants continuing therapy after HBsAg seroconversion was superior to those discontinued prematurely (72.5% vs 54.5% at 96 weeks, P = 0.012). Additionally, the former group was also relatively less likely to experience HBsAg reversion during long-term observation (8.4% vs 14.3% at 96 weeks, P = 0.280). Hepatitis B envelope antigen (HBeAg) status, anti-HBs status and consolidation treatment screened by multivariable analysis were utilized to construct a predictive model for HBsAg reversion. The concordance index(C-index = 0.77) and calibration plots indicated satisfactory discrimination and consistency of nomogram.

Conclusions: HBsAg seroconversion was beneficial for sustaining functional cure in patients treated with peg-IFNα. Continuing consolidation therapy after HBsAg seroconversion also contributed to maintain HBsAg seroconversion and improve the durability of HBsAg loss. The nomogram illustrated its efficacy as a valuable instrument in showcasing survival probability of functional cure.

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乙型肝炎表面抗原血清转换对聚乙二醇干扰素α治疗诱导功能性治愈的持久性的影响。

背景：乙型肝炎表面抗原（HBsAg）消失被认为是评估慢性乙型肝炎（CHB）患者功能性治愈的关键标准。我们开展了这项研究，以调查 HBsAg 血清转换在维持 HBsAg 消失方面的实际表现：这项回顾性分析确认了 295 例通过核苷（t）类似物（NAs）和聚乙二醇干扰素α（peg-IFNα）联合疗法达到 HBsAg 消失的患者。采用 Kaplan-Meier 估计法进行生存分析。森林图用于显示多变量 Cox 回归的结果，并将选定的变量纳入提名图：结果：45 例患者在随访期间观察到 HBsAg 血清学转换，在 peg-IFNα 治疗结束时（EOT），HBsAg 血清学转换患者的复发风险较低（96 周时为 10.3% vs 37.3%，P 结论：HBsAg 血清学转换对患者的治疗有益：HBsAg血清转换有利于维持接受peg-IFNα治疗的患者的功能性治愈。在 HBsAg 血清转换后继续巩固治疗也有助于维持 HBsAg 血清转换并改善 HBsAg 消失的持久性。提名图显示了其作为展示功能性治愈生存概率的重要工具的功效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.