{"title":"The evolutionary advantage of artemisinin production by Artemisia annua.","authors":"Qinggang Yin, Li Xiang, Xiaoyan Han, Yujun Zhang, Ruiqing Lyn, Ling Yuan, Shilin Chen","doi":"10.1016/j.tplants.2024.09.006","DOIUrl":null,"url":null,"abstract":"<p><p>Artemisinin, a potent antimalarial compound, is predominantly derived from Artemisia annua. The uniqueness of artemisinin production in A. annua lies in its complex biochemical pathways and genetic composition, distinguishing it from other plant species, even within the Asteraceae family. In this review, we investigate the potential of A. annua for artemisinin production, drawing evidence from natural populations and mutants. Leveraging high-quality whole-genome sequence analyses, we offer insights into the evolution of artemisinin biosynthesis. We also highlight current understanding of the protective functions of artemisinin in A. annua in response to both biotic and abiotic stresses. In addition, we explore the mechanisms used by A. annua to mitigate the phytotoxicity generated by artemisinin catabolism.</p>","PeriodicalId":23264,"journal":{"name":"Trends in Plant Science","volume":null,"pages":null},"PeriodicalIF":17.3000,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Plant Science","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.tplants.2024.09.006","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Artemisinin, a potent antimalarial compound, is predominantly derived from Artemisia annua. The uniqueness of artemisinin production in A. annua lies in its complex biochemical pathways and genetic composition, distinguishing it from other plant species, even within the Asteraceae family. In this review, we investigate the potential of A. annua for artemisinin production, drawing evidence from natural populations and mutants. Leveraging high-quality whole-genome sequence analyses, we offer insights into the evolution of artemisinin biosynthesis. We also highlight current understanding of the protective functions of artemisinin in A. annua in response to both biotic and abiotic stresses. In addition, we explore the mechanisms used by A. annua to mitigate the phytotoxicity generated by artemisinin catabolism.
期刊介绍：
Trends in Plant Science is the primary monthly review journal in plant science, encompassing a wide range from molecular biology to ecology. It offers concise and accessible reviews and opinions on fundamental plant science topics, providing quick insights into current thinking and developments in plant biology. Geared towards researchers, students, and teachers, the articles are authoritative, authored by both established leaders in the field and emerging talents.
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