Genetic and molecular correlates of cortical thickness alterations in adults with obsessive-compulsive disorder: a transcription-neuroimaging association analysis.

IF 5.9 2区 医学 Q1 PSYCHIATRY
Da Zhang, Changjun Teng, Yinhao Xu, Lei Tian, Ping Cao, Xiao Wang, Zonghong Li, Chengbin Guan, Xiao Hu
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引用次数: 0

Abstract

Background: Although numerous neuroimaging studies have depicted neural alterations in individuals with obsessive-compulsive disorder (OCD), a psychiatric disorder characterized by intrusive cognitions and repetitive behaviors, the molecular mechanisms connecting brain structural changes and gene expression remain poorly understood.

Methods: This study combined the Allen Human Brain Atlas dataset with neuroimaging data from the Meta-Analysis (ENIGMA) consortium and independent cohorts. Later, partial least squares regression and enrichment analysis were performed to probe the correlation between transcription and cortical thickness variation among adults with OCD.

Results: The cortical map of case-control differences in cortical thickness was spatially correlated with cortical expression of a weighted combination of genes enriched for neurobiologically relevant ontology terms preferentially expressed across different cell types and cortical layers. These genes were specifically expressed in brain tissue, spanning all cortical developmental stages. Protein-protein interaction analysis revealed that these genes coded a network of proteins encompassing various highly interactive hubs.

Conclusions: The study findings bridge the gap between neural structure and transcriptome data in OCD, fostering an integrative understanding of the potential biological mechanisms.

强迫症成人皮层厚度改变的遗传和分子相关性:转录-神经影像关联分析。
背景:强迫症是一种以侵入性认知和重复性行为为特征的精神障碍,尽管大量神经影像学研究已经描述了强迫症患者的神经改变,但人们对大脑结构变化和基因表达之间的分子机制仍然知之甚少:本研究将艾伦人类大脑图谱数据集与来自元分析(ENIGMA)联盟和独立队列的神经影像数据相结合。随后,研究人员进行了偏最小二乘法回归和富集分析,以探究强迫症成人患者转录与皮层厚度变化之间的相关性:结果:皮质厚度病例对照差异的皮质图谱与在不同细胞类型和皮质层优先表达的神经生物学相关本体术语的加权组合基因的皮质表达存在空间相关性。这些基因在脑组织中特异性表达,跨越了大脑皮层的所有发育阶段。蛋白质-蛋白质相互作用分析表明,这些基因编码的蛋白质网络包含各种高度交互的枢纽:研究结果弥合了强迫症神经结构与转录组数据之间的差距,促进了对潜在生物学机制的综合理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Psychological Medicine
Psychological Medicine 医学-精神病学
CiteScore
11.30
自引率
4.30%
发文量
711
审稿时长
3-6 weeks
期刊介绍: Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.
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