Urinary benzyl alcohol and hippuric acid in workers exposed to benzyl alcohol during paint-stripping work.

IF 2.6 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Occupational Health Pub Date : 2024-01-04 DOI:10.1093/joccuh/uiae059

Kenta Ishii, Akito Takeuchi, Masami Shimada, Hiromi Momokawa, Tomiko Tashiro, Ai Yamada, Kumiko Arai, Akira Namera, Kenji Yamamuro, Koichi Kato, Toshihiro Kawamoto, Ginji Endo

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引用次数: 0

Abstract

Objective: We aimed to develop a reliable gas chromatography-mass spectrometry (GC-MS) method for detecting urinary benzyl alcohol (BeOH) concentrations and assess the suitability of urinary BeOH as a biomarker for occupational BeOH exposure.

Methods: Thirteen male participants exposed to BeOH during paint-stripping work provided preshift and postshift urine samples, and their personal exposure concentrations were measured. Meanwhile, a control group of 10 nonexposed workers contributed urine samples. The newly developed GC-MS method met regulatory guidelines.

Results: The personal exposure concentrations of BeOH ranged from 8.4 to 45.2 mg/m3. Postshift urine samples from exposed participants showed significant BeOH and hippuric acid (HA) concentration increases compared with preshift samples (BeOH, post-/pre-shift geometric mean [GM] ratio = 7.5-7.8, P < .001; HA, post-/pre-shift GM ratio = 4.3-4.5, P < .001). These levels were considerably higher than those in postshift samples from the nonexposed control group (BeOH, exposed-/nonexposed-workers GM ratio = 14.8-19.0, P < .001; HA, exposed-/nonexposed-workers GM ratio = 12.1-15.3, P < .001), even after urine density correction.

Conclusions: Urinary BeOH and HA can serve as potential biomarkers of occupational exposure to BeOH. More specifically, BeOH might serve as a biomarker superior to HA because it is apparently less influenced by confounding factors such as dietary intake and genetic polymorphism of low-Km aldehyde dehydrogenase (ALDH2). The findings will improve workplace safety measures and protocols, assisting health care professionals in diagnosing and managing exposure-related health issues, thereby potentially reducing the risk of occupational exposure to BeOH.

查看原文本刊更多论文

在脱漆工作中接触苯甲醇的工人尿液中的苯甲醇和喜树酸。

研究目的本研究旨在开发一种可靠的气相色谱-质谱（GC-MS）方法，用于检测尿液中的苯甲醇（BeOH）浓度，并评估其作为职业性苯甲醇暴露的生物标志物的适用性：方法：13 名在脱漆工作中接触 BeOH 的男性参与者提供了班前和班后尿液样本，并测量了他们的个人接触浓度。同时，由 10 名未接触过 BeOH 的工人组成的对照组也提供了尿样。新开发的气相色谱-质谱法符合法规要求：结果：BeOH 的个人暴露浓度介于 8.4 至 45.2 mg/m3 之间。与班前尿样相比，接触者班后尿样中的 BeOH 和马尿酸（HA）浓度明显增加（BeOH，班后/班前几何平均（GM）比值 = 7.5-7.8，p 结论：尿样中的 BeOH 和 HA 可作为一种有毒物质，对人体健康和环境造成危害：尿液中的 BeOH 和 HA 可作为职业暴露于 BeOH 的潜在生物标志物。更具体地说，BeOH可能是比HA更好的生物标志物，因为它受膳食摄入量和低Km醛脱氢酶（ALDH2）基因多态性等混杂因素的影响较小。这些研究结果将改进工作场所的安全措施和规程，帮助医疗保健专业人员诊断和管理与暴露有关的健康问题，从而降低职业暴露于 BeOH 的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Occupational Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.60

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The scope of the journal is broad, covering toxicology, ergonomics, psychosocial factors and other relevant health issues of workers, with special emphasis on the current developments in occupational health. The JOH also accepts various methodologies that are relevant to investigation of occupational health risk factors and exposures, such as large-scale epidemiological studies, human studies employing biological techniques and fundamental experiments on animals, and also welcomes submissions concerning occupational health practices and related issues.