Seizure recurrence following the first unprovoked seizure: Risk factors among children in UAE

IF 1.7 4区医学 Q3 DEVELOPMENTAL BIOLOGY

International Journal of Developmental Neuroscience Pub Date : 2024-10-04 DOI:10.1002/jdn.10382

Dina Amin Saleh, Abeera Hassan

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引用次数: 0

Abstract

In a retrospective study of paediatric and adolescent patients in Abu Dhabi, UAE, who experienced their first unprovoked seizure between March 2016 and March 2020, with a minimum one-year follow-up, we identified significant risk factors associated with seizure recurrence. Among 317 patients, 96.2% experienced seizure recurrence, with the majority (68.8%) occurring within the first 6-month follow-up period. Notable risk factors for recurrence included focal seizures, symptomatic seizure causes, abnormal initial electroencephalogram (EEG) findings, abnormal brain magnetic resonance imaging results, and the presence of neurological disorders. Interestingly, the type of epileptiform activity in the initial EEG did not predict recurrence risk. Over a 3-year period, the overall recurrence risk was 98.4%, particularly higher in cases with symptomatic seizures compared to idiopathic (genetic) ones. These findings underscore the importance of vigilant monitoring, particularly in the early post-seizure follow-up period, and advocate for initial EEG assessments, especially in cases of remote symptomatic first unprovoked seizures.

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首次无诱因癫痫发作后的癫痫复发：阿联酋儿童的风险因素。

我们对阿联酋阿布扎比在 2016 年 3 月至 2020 年 3 月期间首次出现无诱因癫痫发作、随访至少一年的儿童和青少年患者进行了一项回顾性研究，发现了与癫痫复发相关的重要风险因素。在 317 名患者中，96.2% 的患者经历过癫痫复发，其中大部分（68.8%）发生在最初 6 个月的随访期内。复发的显著风险因素包括：局灶性癫痫发作、症状性癫痫发作原因、初始脑电图（EEG）结果异常、脑磁共振成像结果异常以及存在神经系统疾病。有趣的是，初始脑电图中癫痫样活动的类型并不能预测复发风险。在 3 年的时间里，总体复发风险为 98.4%，尤其是症状性癫痫发作病例的复发风险高于特发性（遗传性）癫痫发作病例。这些发现强调了警惕性监测的重要性，尤其是在癫痫发作后的早期随访阶段，并提倡进行初始脑电图评估，特别是在远端症状性首次无诱因癫痫发作的病例中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Developmental Neuroscience 医学-发育生物学

CiteScore

3.30

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.